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Purified anti-human CD45RA Antibody
产品名称：
Purified anti-human CD45RA Antibody
产品类别：
抗体
产品编号：
304102
产品应用：
304102
[价格]
规格 价格 库存
100µg ￥ 528 1

产品详情

Product Details

Verified Reactivity
Human
Reported Reactivity
Chimpanzee
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
CyTOF? - Verified
ICC, IHC-F, IHC-P, PG - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for relevant formats of this clone) include: inhibition of CD45 functions2, immunohistochemical staining of frozen tissue sections3 and formalin-fixed paraffin-embedded tissue sections4, and immunocytochemistry15,16.

Application References

(PubMed link indicates BioLegend citation)
  1. Knapp W, et al. 1989. Leucocyte Typing IV. Oxford University Press. New York.
  2. Yamada T, et al. 2002. J. Biol. Chem. 277:28830. (WB, Block)
  3. Weninger W, et al. 2003 J. Immunol. 170:4638. (IHC-F)
  4. Imanguli MM, et al. 2009. Blood. 113:3620 (IHC-P)
  5. Roque S, et al. 2007. J. Immunol. 178:8028. (FC) PubMed
  6. Smeltz RB. 2007. J. Immunol. 178:4786. (FC) PubMed
  7. Palendira U, et al. 2008. Blood (FC) PubMed
  8. Kuttruff S, et al. 2009. Blood 113:358. (FC) PubMed
  9. Thakral D, et al. 2008. J. Immunol. 180:7431. (FC) PubMed
  10. Alanio C, et al. 2010. Blood 115:3718. (FC) PubMed
  11. Iannello A, et al. 2010. J. Immunol. 184:114. (FC) PubMed
  12. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
  13. Guereau-de-Arellan M, et al. 2011. Brain. 134:3578. PubMed
  14. Canque B, et al. 2000. Blood 96:3748. (ICC)
  15. Imanguli MM, et al. 2009. Blood 13:3620. (ICC)
  16. Stoeckius M, et al. 2017. Nat. Methods. 14:865. (PG)
  17. Peterson VM, et al. 2017. Nat. Biotechnol. 35:936. (PG)
Product Citations
  1. S?gaard O, et al. 2015. PLoS One. 11: 1005142. PubMed
  2. Apte SH, et al. 2020. Clin Transl Immunology. 9:e1209. PubMed
  3. Alcántara‐Hernández M et al. 2017. Immunity. 47(6):1037-1050 . PubMed
  4. Sullivan KD, et al. 2021. Cell Reports. 36(7):109527. PubMed
  5. Taft J, et al. 2021. Cell. 184(17):4447-4463.e20. PubMed
  6. Wagner J et al. 2019. Cell. 177(5):1330-1345 . PubMed
  7. Damond N, et al. 2019. Cell Metab. 29:755. PubMed
  8. Bobardt M, et al. 2020. PLoS One. 15:e0227715. PubMed
  9. Mann ER, et al. 2020. Sci Immunol. :5. PubMed
  10. Kaufmann M, et al. 2021. Med. 2(3):296-312.e8. PubMed
  11. Alcántara-Hernández M, et al. 2021. Nat Protoc. 16:4855. PubMed
  12. Kondo H, et al. 2022. Front Immunol. 13:836923. PubMed
  13. Yoshihara S, et al. 2019. Front Immunol. 0.545833333. PubMed
  14. Taylor JG, et al. 2022. Haematologica. :. PubMed
  15. Yang R, et al. 2020. Cell. 183(7):1826-1847.e31. PubMed
  16. Gunawan M, et al. 2017. Sci Rep. . 10.1038/s41598-017-16999-7. PubMed
  17. Martin JC, et al. 2020. Cell. 178(6):1493-1508.e20.. PubMed
  18. Michlmayr D, et al. 2020. Cell Reports. 31(4):107569. PubMed
  19. Hsiao F, et al. 2020. PLoS Pathog. 16:e1008450. PubMed
  20. Ga?án-Gómez I, et al. 2022. Nat Med. . PubMed
  21. Zhang Y, et al. 2020. Front Immunol. 11:1012. PubMed
  22. Syrimi E, et al. 2021. iScience. 24:103215. PubMed
  23. O'Boyle KC, et al. 2020. Methods Mol Biol. 2111:1. PubMed
  24. Cobb DA, et al. 2022. J Immunother Cancer. 10:. PubMed
  25. Galbraith MD, et al. 2021. eLife. 10:00. PubMed
  26. Wastyk HC, et al. 2021. Cell. 184(16):4137-4153.e14. PubMed
  27. Baskar R, et al. 2022. Cell Rep Methods. 2:. PubMed
  28. Zhao J, et al. 2017. Sci Immunol. 2:eaan5400. PubMed
  29. Sattler A, et al. 2021. Am J Transplant. 21:87. PubMed
  30. Hunter S, et al. 2018. J Hepatol. 69:654. PubMed
  31. Lückel C, et al. 2019. Nat Commun. 4.390277778. PubMed
  32. Roussel M, et al. 2021. Cell Reports Medicine. 2(6):100291. PubMed
  33. Wu Y, et al. 2007. Infect Immun . 178:2802. PubMed
  34. Singh AK, et al. 2017. Front Immunol. 0.513888889. PubMed
  35. Mishra A, et al. 2021. Cell. 184(13):3394-3409.e20. PubMed
  36. Lazarski CA, et al. 2020. Cytotherapy. . PubMed
  37. Evrard M et al. 2018. Immunity. 48(2):364-379 . PubMed
  38. Nicolet BP, et al. 2017. J Immunol. 198:962. PubMed
  39. Majri SS, et al. 2018. J Immunol. 200:110. PubMed
  40. Guerau-de-Arellano M, et al. 2011. Brain. 134:3578. PubMed
  41. NULL, et al. 2022. Cell. 185:916. PubMed
  42. Oda H, et al. 2019. Front Immunol. 10:479. PubMed
  43. Kennedy-Darling J, et al. 2021. Eur J Immunol. 51:1262. PubMed
  44. Wadley AJ, et al. 2020. Brain Behav Immun Health. 3:100049. PubMed
  45. Waugh KA, et al. 2020. Cell Reports. 29(7):1893-1908.e4.. PubMed
  46. Martin E, et al. 2020. JCI Insight. :5. PubMed
  47. Leylek R, et al. 2020. Cell Rep. 32:108180. PubMed
  48. Lavin Y et al. 2017. Cell. 169(4):750-765 . PubMed
  49. Dutertre CA, et al. 2020. Immunity. 51(3):573-589.e8.. PubMed
  50. Umeda M, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
RRID
AB_314406 (BioLegend Cat. No. 304102)

Antigen Details

Structure
Tyrosine phosphatases, type I transmembrane (exon 4 splicing of CD45 gene), 205-220 kD
Distribution

B cells, na?ve T cells, monocytes

Function
Enhances TCR and BCR signaling
Ligand/Receptor
Galectin-1, CD2, CD3, CD4
Cell Type
B cells, Monocytes, T cells, Tregs
Biology Area
Cell Biology, Immunology, Inhibitory Molecules, Neuroscience, Neuroscience Cell Markers
Molecular Family
CD Molecules
Antigen References

1. Thomas M. 1989. Annu. Rev. Immunol. 7:339.
2. Trowbridge I, et al. 1994. Annu. Rev. Immunol.12:85.

Gene ID
5788 View all products for this Gene ID
UniProt
View information about CD45RA on UniProt.org

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