APC/Cyanine7 anti-human CD45RA Antibody
- 产品名称：
- APC/Cyanine7 anti-human CD45RA Antibody
- 产品类别：
- 抗体
- 产品编号：
- 304127
- 产品应用：
- 304127
[价格]
| 规格 |
价格 |
库存 |
| 25tests |
￥ 1656 |
1 |
- Verified Reactivity
- Human
- Reported Reactivity
- Chimpanzee
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC/Cyanine7 under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
- Excitation Laser
- Red Laser (633 nm)
- Application Notes
Additional reported applications (for relevant formats of this clone) include: inhibition of CD45 functions2, immunohistochemical staining of frozen tissue sections3 and formalin-fixed paraffin-embedded tissue sections4, and immunocytochemistry15,16.
- Additional Product Notes
- BioLegend is in the process of converting the name APC/Cy7 to APC/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our APC/Cyanine7 products. Please contact Technical Service if you have any questions.
- Application References
(PubMed link indicates BioLegend citation) -
- Knapp W, et al. 1989. Leucocyte Typing IV. Oxford University Press. New York.
- Yamada T, et al. 2002. J. Biol. Chem. 277:28830. (WB, Block)
- Weninger W, et al. 2003 J. Immunol. 170:4638. (IHC-F)
- Imanguli MM, et al. 2009. Blood. 113:3620 (IHC-P)
- Roque S, et al. 2007. J. Immunol. 178:8028. (FC) PubMed
- Smeltz RB. 2007. J. Immunol. 178:4786. (FC) PubMed
- Palendira U, et al. 2008. Blood (FC) PubMed
- Kuttruff S, et al. 2009. Blood 113:358. (FC) PubMed
- Thakral D, et al. 2008. J. Immunol. 180:7431. (FC) PubMed
- Alanio C, et al. 2010. Blood 115:3718. (FC) PubMed
- Iannello A, et al. 2010. J. Immunol. 184:114. (FC) PubMed
- Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
- Guereau-de-Arellan M, et al. 2011. Brain. 134:3578. PubMed
- Canque B, et al. 2000. Blood 96:3748. (ICC)
- Imanguli MM, et al. 2009. Blood 13:3620. (ICC)
- Stoeckius M, et al. 2017. Nat. Methods. 14:865. (PG)
- Peterson VM, et al. 2017. Nat. Biotechnol. 35:936. (PG)
- Product Citations
-
- Liu Y, et al. 2022. Signal Transduct Target Ther. 7:347. PubMed
- Chagraoui J, et al. 2021. Cell Stem Cell. 28(1):48-62.e6. PubMed
- Shoda H, et al. 2017. Arthritis Research & Therapy . 10.1186/s13075-017-1308-y. PubMed
- Berres M, et al. 2014. J Exp Med. 211:669. PubMed
- Ishizaka A, et al. 2016. J Virol. 90: 5665 - 5676. PubMed
- Nagafuchi Y, et al. 2016. Sci Rep. 6:29338. PubMed
- Ho T, et al. 2016. Blood. 128: 1671 - 1678. PubMed
- Yamauchi T et al. 2018. Cancer cell. 33(3):386-400 . PubMed
- Todd J, et al. 2016. PLoS Med. 13:e1002139. PubMed
- Karlsson H, et al. 2015. PLoS One. 10: 0144787. PubMed
- Qi Q, et al. 2016. PLoS Pathog. 12:e1005892. PubMed
- Bj?rklund &, et al. 2016. Nat Immunol. 17:451-460. PubMed
- Ma X et al. 2019. eLife. 8 pii: e42426. PubMed
- Xiao X, et al. 2019. Cell Discov. 5:2. PubMed
- Hu W, et al. 2021. Vaccines (Basel). 9:. PubMed
- Masson J, et al. 2017. PLoS One.. 10.1371/journal.pone.0183931. PubMed
- Zheng S, et al. 2018. Mol Syst Biol. 14:e8041. PubMed
- Wilson AS, et al. 2022. Nat Commun. 13:528. PubMed
- Wang X, et al. 2021. Cell Discovery. 7(1):60. PubMed
- Bulgarelli J, et al. 2021. Front Immunol. 12:778459. PubMed
- Jung JH, et al. 2021. Nat Commun. 12:4043. PubMed
- Nakasone H, et al. 2021. Commun Biol. 4:1177. PubMed
- Collins DR, et al. 2021. Immunity. 54:2372. PubMed
- Nakachi S, et al. 2017. Arthritis Research & Therapy . 10.1186/s13075-017-1309-x. PubMed
- Chen Y, et al. 2020. Cell. 1496:183. PubMed
- Kim MY, et al. 2022. Nat Commun. 13:3296. PubMed
- Keller B, et al. 2016. J Exp Med. 213: 1185 - 1199. PubMed
- Beyer M, et al. 2016. Nat Immunol. 17:593-603. PubMed
- Crippa S, et al. 2019. J Clin Invest. 129:1566. PubMed
- Yamaguchi K, et al. 2018. Cancer Sci. 109:3032. PubMed
- Tomellini E, et al. 2020. Cell Reports. 28(4):1063-1073.e5.. PubMed
- Mann EH, et al. 2019. J Immunol. 202:684. PubMed
- RRID
- AB_10708419 (BioLegend Cat. No. 304127) AB_10708880 (BioLegend Cat. No. 304128)
- Structure
- Tyrosine phosphatases, type I transmembrane (exon 4 splicing of CD45 gene), 205-220 kD
- Distribution
-
B cells, na?ve T cells, monocytes
- Function
- Enhances TCR and BCR signaling
- Ligand/Receptor
- Galectin-1, CD2, CD3, CD4
- Cell Type
- B cells, Monocytes, T cells, Tregs
- Biology Area
- Cell Biology, Immunology, Inhibitory Molecules, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- CD Molecules
- Antigen References
-
1. Thomas M. 1989. Annu. Rev. Immunol. 7:339.
2. Trowbridge I, et al. 1994. Annu. Rev. Immunol.12:85.
- Gene ID
- 5788 View all products for this Gene ID
- UniProt
- View information about CD45RA on UniProt.org
