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Purified anti-human C3AR Antibody
产品名称:
Purified anti-human C3AR Antibody
产品类别:
抗体
产品编号:
345802
产品应用:
345802
[价格]
规格 价格 库存
100µg ¥ 2748 1

产品详情

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
hC3aR transfected cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
IHC-F - Reported in the literature, not verified in house

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 ?g per 106 cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen sections2.

Application References

(PubMed link indicates BioLegend citation)
  1. Soruri A, et al. 2002. J. Immunol. 170:3306 (FC)
  2. Kiafard Z, et al. 2007 Immunobiology. 212:129 (FC, IHC)
Product Citations
  1. Bonetti P, et al. 2013. Blood. 122:2233. PubMed
RRID
AB_2066747 (BioLegend Cat. No. 345802)

Antigen Details

Structure
482 aa, single chain protein with seven membrane-spanning regions, 54 kD
Distribution

Neutrophils, eosinophils, mast cells, monocytes, dendritic cells, hematopoietic and mesenchymal stem cells, endothelial cells

Function
After C3a binding, the C3AR signaling results in chemotaxis, granule enzyme release and superoxide anion production.
Interaction
G proteins
Bioactivity
Chemotaxis, degranulation
Cell Type
Dendritic cells, Endothelial cells, Eosinophils, Mast cells, Mesenchymal Stem Cells, Monocytes, Neutrophils
Biology Area
Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroinflammation, Neuroscience, Stem Cells
Molecular Family
Cytokine/Chemokine Receptors
Antigen References

1. Wysoczynski M et al. 2009. Leukemia. 23:1455
2. Schraufstatter IU. et al. 2009. J. Immunol. 182:3827
3. Honczarenko M et al. 2005. J. Immunol. 175:3698
4. Reca R et al. 2003. Blood 101:3784

Gene ID
719 View all products for this Gene ID
UniProt
View information about C3aR on UniProt.org

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