PE anti-ASC (TMS-1) Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25tests	￥ 1980	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Recombinant human ASC (aa 113-195).

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)

Preparation

The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.

Concentration

Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Application

ICFC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser

Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)

Application References (PubMed link indicates BioLegend citation)

Product Citations

RRID

AB_2564507 (BioLegend Cat. No. 653903) AB_2564508 (BioLegend Cat. No. 653904)

Structure: 195 amino acids with a predicted molecular weight of 21 kD.
Distribution: Cytoplasm
Function: ASC promotes caspase-mediated apoptosis. This pro-apoptotic activity is mediated predominantly through the activation of caspase-9. ASC is an integral component of the inflammasome. Within the inflammasome ASC links caspase-1 and NOD-like receptors (NLR) leading to the activation of caspase-1.
Interaction: Interacts with CIAS1/PYPAF1 and PYDC1.
Cell Type: B cells
Biology Area: Cell Biology, Immunology, Neuroscience
Antigen References: 1. Masumoto J, et al. 1999. J. Biol. Chem. 274:33835.
2. Conway KE, et al. 2000. Cancer Res. 60:6236.
3. Strong R, et al. 1991. Brain Res. 542:23.
4. Ohtsuka T, et al. 2004. Nat. Cell Biol. 6:121.
5. Srinivasula SM, et al. 2002. J. Biol. Chem. 277:21119.
6. Ippagunta SK, et al. 2010. J. Biol. Chem. 285:12454.
Gene ID: 29108 View all products for this Gene ID
UniProt: View information about ASC on UniProt.org