APC anti-human CD62E Antibody
- 产品名称：
- APC anti-human CD62E Antibody
- 产品类别：
- 抗体
- 产品编号：
- 336011
- 产品应用：
- 336011
[价格]
| 规格 |
价格 |
库存 |
| 25tests |
￥ 1704 |
1 |
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
- Excitation Laser
- Red Laser (633 nm)
- Application Notes
Additional reported applications: blocks CD62E binding to its ligand
- Application References
(PubMed link indicates BioLegend citation) -
- Tu L, et al. 1996. J. Immunol. 157:3995
- Zhang Y and S. Neelamegham. 2002. Biophys. J. 83:1934
- Product Citations
-
- Tzoran I, et al. 2015. Exp Hematol. . PubMed
- Hijmans JG, et al. 2019. J Am Heart Assoc. 8:e011134. PubMed
- Barbier V, et al. 2020. Nat Commun. 11:2042. PubMed
- Jeffery H, et al. 2013. J Virol. 87:6530. PubMed
- RRID
- AB_2254490 (BioLegend Cat. No. 336011) AB_2186829 (BioLegend Cat. No. 336012)
- Structure
- Member of the selectin family, 115 kD type I membrane protein; contains one C-type lectin domain and one EGF-like domain
- Distribution
-
Highly expressed on activated endothelial cells (IL-2, TNF-α), other cytokines can increase expression); can also be expressed on endothelial cells in the skin, bone marrow and placenta.
- Function
- Involved in tethering and leucocyte rolling on activated endothelium at inflammatory sites, may also play a role in tumor metastasis and angiogenesis
- Ligand/Receptor
- Siayl Lewis X (CD15s) and PSGL-1 (CD162) bind to CD62E. Recently, CLA (cutaneous lymphocyte antigen) has also been reported in interact with CD62E
- Cell Type
- Endothelial cells
- Biology Area
- Angiogenesis, Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
-
1. Collins T, et al. 1991. J. Biol. Chem. 266:2466
2. Bevilacqua MP, et al. 1987. Proc. Natl. Acad. Sci. USA 84:9238
3. Berg EL, et al. 1991. J. Exp. Med. 174:1461.
4. Lawrence MB, et al. 1993. J. Immunol. 151:6338.
5. Walz G, et al. 1990. Science 250:1132
- Gene ID
- 6401 View all products for this Gene ID
- UniProt
- View information about CD62E on UniProt.org
