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首页 > 抗体蛋白 > 抗体
Purified anti-mouse TCR β chain Antibody
产品名称：
Purified anti-mouse TCR β chain Antibody
产品类别：
抗体
产品编号：
109201
产品应用：
109201
[价格]
规格 价格 库存
50µg ￥ 648 1

产品详情

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
Affinity purified TCR from mouse DO-11.10 cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
CyTOF?, IHC-F? - Verified
IP, Costim, Depletion - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 ?g per 106 cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

H57-597 is a hamster mAb directed to an epitope of the C region of TCR ? chain12. The H57-597 antibody does not cross-react with ?/d TCR-bearing T cells. Immobilized or soluble H57-597 antibody can activate a/? TCR-bearing T cells. Additional reported applications (for the relevant formats) for this antibody include: immunoprecipitation2, in vitro stimulation2,3, in vivo depletion4-6, and immunohistochemical staining of acetone-fixed frozen sections7,8,9. The Ultra-LEAF? purified antibody (Endotoxin <0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. No. 109253-109258).

Application References

(PubMed link indicates BioLegend citation)
  1. Gascoigne NJ. 1990. J. Biol. Chem. 265:9296.
  2. Kruisbeek A, et al. 1991. In Current Protocols in Immunology. pp. 3.12.1. (Costim IP)
  3. Davenport C, et al. 1995. J. Immunol. 155:3742. (Costim)
  4. Drobyski W, et al. 1996. Blood 87:5355. (Deplete)
  5. Kummer U, et al. 2001. Immunol. Lett. 75:153. (Deplete)
  6. van der Heyde HC, et al. 1995. J. Immunol. 154:3985. (Deplete)
  7. Tomita K, et al. 1999. Genes Dev. 13:1203. (IHC)
  8. Podd BS, et al. 2006. J. Immunol. 176:6532. (IHC)
  9. Ponomarev ED, et al. 2007. J. Immunol. 178:39. (IHC)
  10. Chappaz S, et al. 2007. Blood doi:10.1182/blood-2007-02-074245. (FC) PubMed
  11. Tsukumo S, et al. 2006. J.Immunol. 177:8365. (FC) PubMed
  12. Grégoire C, et al. 1991. Proc. Natl. Acad. Sci USA 88:8077.
Product Citations
  1. Hernández-Santana YE, et al. 2020. Life Sci Alliance. 3:00. PubMed
  2. Arnold IC, et al. 2019. PLoS Pathog. 15:e1007866. PubMed
  3. Tsukumo S, et al. 2006. J Immunol. 177:8365. PubMed
  4. Hutton C, et al. 2021. Cancer Cell. 39:1227. PubMed
  5. Paterson MJ, et al. 2020. PLoS Pathog. 16:e1008733. PubMed
  6. Tersteegen A, et al. 2021. Infect Immun. 89:. PubMed
  7. McDole J, et al. 2010. Am J Pathol. 177:1823. PubMed
  8. Krovi SH, et al. 2019. Proc Natl Acad Sci U S A. 116:22252. PubMed
  9. Landuyt AE, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  10. Khan KA, et al. 2020. NPJ Breast Cancer. 6:29. PubMed
  11. Arnold IC, et al. 2018. J Exp Med. 215:2055. PubMed
  12. Tan A, et al. 2017. J Autoimmun.. 10.1016/j.jaut.2017.11.004. PubMed
  13. Dienz O, et al. 2020. J Immunol. 204:1521. PubMed
  14. Willimsky G, et al. 2021. Elife. 10:. PubMed
  15. Goodall KJ, et al. 2021. J Biol Chem. 297:101141. PubMed
  16. Nakamizo S,et al. 2017. Sci Rep. . 10.1038/s41598-017-14292-1. PubMed
  17. Lee JH, et al. 2022. iScience. 25:104166. PubMed
  18. Peng V, et al. 2020. J Biol Chem. 295:14866. PubMed
  19. Doorduijn EM, et al. 2018. Front Immunol. 0.416666667. PubMed
  20. Khan KA, et al. 2020. NPJ Breast Cancer. 6:29. PubMed
  21. Hilligan KL, et al. 2020. Nat Commun. 11:5637. PubMed
  22. Snell LM, et al. 2018. Immunity. 49:678. PubMed
  23. Overacre-Delgoffe AE, et al. 2017. Cell. 169:1130. PubMed
  24. Sharba S, et al. 2019. Virulence. 10:97. PubMed
  25. Chappaz S, et al. 2007. Blood. 110:3862. PubMed
  26. Lai JF, et al. 2020. J Allergy Clin Immunol. 146:1406. PubMed
  27. Xie D, et al. 2020. Eur J Immunol. 50:1729. PubMed
  28. Liu H, et al. 2020. J Immunol. 205:1207. PubMed
  29. Kim SJ, et al. 2017. Nat Immunol. 18:1016. PubMed
  30. Hsiao CC, et al. 2021. Cells. 10:. PubMed
  31. Bittner-Eddy PD, et al. 2020. Front Immunol. 11:677. PubMed
  32. Cardoso F, et al. 2021. Nature. 597:410. PubMed
  33. Dooley K, et al. 2021. Mol Ther. 29:1729. PubMed
  34. Sharabi A, et al. 2019. JCI Insight. 4:e126294. PubMed
  35. Tao H, et al. 2021. Front Immunol. 12:623280. PubMed
  36. Clark K, et al. 2019. Front Immunol. 10:2355. PubMed
  37. Yates K, et al. 2018. Proc Natl Acad Sci U S A. 115:2162. PubMed
  38. Simula L et al. 2018. Cell reports. 25(11):3059-3073 . PubMed
  39. Gubin MM, et al. 2018. Cell. 175:1014. PubMed
  40. Wang HC, et al. 2017. J Immunol. 198:3149. PubMed
  41. Tan CL, et al. 2018. Immunohorizons. 0.248611111. PubMed
  42. Karmaus PWF, et al. 2019. Nature. 565:101. PubMed
  43. Chen X, et al. 2019. Methods Mol Biol. 2048:131. PubMed
  44. Kawabe T, et al. 2017. Sci Immunol. 2:eaam9315. PubMed
  45. Roussey JA, et al. 2017. J Immunol. 199:3535. PubMed
  46. Xu W, et al. 2021. Immunity. 54(3):526-541.e7. PubMed
  47. Lee B, et al. 2019. Front Immunol. 0.561805556. PubMed
  48. Lin J, et al. 2017. Nat Commun. . 10.1038/s41467-017-01477-5. PubMed
  49. Sugiyarto G, et al. 2021. Immunother Adv. 1:ltaa001. PubMed
  50. An Y et al. 2018. Cell reports. 25(3):702-714 . PubMed
  51. Dubik M, et al. 2021. Front Neurosci. 15:682451. PubMed
  52. Fritz Y, et al. 2017. J Invest Dermatol. 137:696. PubMed
RRID
AB_313424 (BioLegend Cat. No. 109201) AB_313425 (BioLegend Cat. No. 109202)

Antigen Details

Structure
Ig superfamily, CD3/TCR complex with CD3 and TCR α subunit
Distribution

Majority of T cells and thymocytes (correlated to differentiation)

Function
Antigen recognition, T cell activation
Ligand/Receptor
Peptide bound-MHC class I and II
Antigen References

1. Davis MM, et al. 1998. Ann. Rev. Immunol. 16:523.
2. Huppa JB, et al. 2003. Nat. Immunol. 4:749.
3. Kubo R, et al. 1989. J. Immunol. 142:2736.

Gene ID
21577 View all products for this Gene ID
UniProt
View information about TCR beta chain on UniProt.org

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