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首页 > 抗体蛋白 > 抗体
FITC anti-mouse TCR β chain Antibody
产品名称：
FITC anti-mouse TCR β chain Antibody
产品类别：
抗体
产品编号：
109205
产品应用：
109205
[价格]
规格 价格 库存
50µg ￥ 564 1

产品详情

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
Affinity purified TCR from mouse DO-11.10 cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Application Notes

H57-597 is a hamster mAb directed to an epitope of the C region of TCR ? chain12. The H57-597 antibody does not cross-react with ?/d TCR-bearing T cells. Immobilized or soluble H57-597 antibody can activate a/? TCR-bearing T cells. Additional reported applications (for the relevant formats) for this antibody include: immunoprecipitation2, in vitro stimulation2,3, in vivo depletion4-6, and immunohistochemical staining of acetone-fixed frozen sections7,8,9. The Ultra-LEAF? purified antibody (Endotoxin <0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. No. 109253-109258).

Application References

(PubMed link indicates BioLegend citation)
  1. Gascoigne NJ. 1990. J. Biol. Chem. 265:9296.
  2. Kruisbeek A, et al. 1991. In Current Protocols in Immunology. pp. 3.12.1. (Costim IP)
  3. Davenport C, et al. 1995. J. Immunol. 155:3742. (Costim)
  4. Drobyski W, et al. 1996. Blood 87:5355. (Deplete)
  5. Kummer U, et al. 2001. Immunol. Lett. 75:153. (Deplete)
  6. van der Heyde HC, et al. 1995. J. Immunol. 154:3985. (Deplete)
  7. Tomita K, et al. 1999. Genes Dev. 13:1203. (IHC)
  8. Podd BS, et al. 2006. J. Immunol. 176:6532. (IHC)
  9. Ponomarev ED, et al. 2007. J. Immunol. 178:39. (IHC)
  10. Chappaz S, et al. 2007. Blood doi:10.1182/blood-2007-02-074245. (FC) PubMed
  11. Tsukumo S, et al. 2006. J.Immunol. 177:8365. (FC) PubMed
  12. Grégoire C, et al. 1991. Proc. Natl. Acad. Sci USA 88:8077.
Product Citations
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  12. Gómez-Díaz C, et al. 2021. iScience. 24:103241. PubMed
  13. Anderson CK et al. 2019. Cell Rep. 27(2):537-548 . PubMed
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  19. Fennell LM, et al. 2020. EMBO J. 39:e103303. PubMed
  20. Ng SS, et al. 2020. Nat Immunol. 21:1205. PubMed
  21. Trefzer A, et al. 2021. Cell Reports. 34(6):108748. PubMed
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  24. Germundson DL, et al. 2022. Front Allergy. 3:870513. PubMed
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  28. Frost JN, et al. 2021. Med (N Y). 2:164. PubMed
  29. Lebel M?, et al. 2020. Nat Commun. 3.051388889. PubMed
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  31. Miyauchi E, et al. 2020. Nature. 585:102. PubMed
  32. Liang Q, et al. 2020. Front Microbiol. 11:571847. PubMed
  33. Da Mesquita S, et al. 2021. Science Advances. 7(21):. PubMed
  34. Diercks BP, et al. 2018. Sci Signal. 11:eaat0358. PubMed
  35. Li F, et al. 2022. Nat Commun. 13:4334. PubMed
  36. Rustenhoven J, et al. 2021. Cell. 184(4):1000-1016.e27. PubMed
  37. Baglaenko Y, et al. 2016. PLoS One. 11: 0150515. PubMed
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  39. Shimba A et al. 2018. Immunity. 48(2):286-298 . PubMed
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  41. Fujimoto M, et al. 2022. Nat Commun. 13:5408. PubMed
  42. Hackstein CP, et al. 2022. Nat Commun. 13:7472. PubMed
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  44. Chew HY, et al. 2020. Cell. 180(5):895-914. PubMed
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RRID
AB_313428 (BioLegend Cat. No. 109205) AB_313429 (BioLegend Cat. No. 109206)

Antigen Details

Structure
Ig superfamily, CD3/TCR complex with CD3 and TCR α subunit
Distribution

Majority of T cells and thymocytes (correlated to differentiation)

Function
Antigen recognition, T cell activation
Ligand/Receptor
Peptide bound-MHC class I and II
Antigen References

1. Davis MM, et al. 1998. Ann. Rev. Immunol. 16:523.
2. Huppa JB, et al. 2003. Nat. Immunol. 4:749.
3. Kubo R, et al. 1989. J. Immunol. 142:2736.

Gene ID
21577 View all products for this Gene ID
UniProt
View information about TCR beta chain on UniProt.org

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