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Brilliant Violet 605™ anti-mouse TCR β
产品名称：
Brilliant Violet 605™ anti-mouse TCR β
产品类别：
抗体
产品编号：
109241
产品应用：
109241
[价格]
规格 价格 库存
50µg ￥ 3144 1

产品详情

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
Affinity purified TCR from mouse DO-11.10 cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
Preparation
The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 605? under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Brilliant Violet 605? excites at 405 nm and emits at 603 nm. The bandpass filter 610/20 nm is recommended for detection, although filter optimization may be required depending on other fluorophores used. Be sure to verify that your cytometer configuration and software setup are appropriate for detecting this channel. Refer to your instrument manual or manufacturer for support. Brilliant Violet 605? is a trademark of Sirigen Group Ltd.


Learn more about Brilliant Violet?.

This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.
Excitation Laser
Violet Laser (405 nm)
Application Notes

H57-597 is a hamster mAb directed to an epitope of the C region of TCR ? chain12. The H57-597 antibody does not cross-react with ?/d TCR-bearing T cells. Immobilized or soluble H57-597 antibody can activate a/? TCR-bearing T cells. Additional reported applications (for the relevant formats) for this antibody include: immunoprecipitation2, in vitro stimulation2,3, in vivo depletion4-6, and immunohistochemical staining of acetone-fixed frozen sections7,8,9. The Ultra-LEAF? purified antibody (Endotoxin <0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. No. 109253-109258).

Application References

(PubMed link indicates BioLegend citation)
  1. Gascoigne NJ. 1990. J. Biol. Chem. 265:9296.
  2. Kruisbeek A, et al. 1991. In Current Protocols in Immunology. pp. 3.12.1. (Costim IP)
  3. Davenport C, et al. 1995. J. Immunol. 155:3742. (Costim)
  4. Drobyski W, et al. 1996. Blood 87:5355. (Deplete)
  5. Kummer U, et al. 2001. Immunol. Lett. 75:153. (Deplete)
  6. van der Heyde HC, et al. 1995. J. Immunol. 154:3985. (Deplete)
  7. Tomita K, et al. 1999. Genes Dev. 13:1203. (IHC)
  8. Podd BS, et al. 2006. J. Immunol. 176:6532. (IHC)
  9. Ponomarev ED, et al. 2007. J. Immunol. 178:39. (IHC)
  10. Chappaz S, et al. 2007. Blood doi:10.1182/blood-2007-02-074245. (FC) PubMed
  11. Tsukumo S, et al. 2006. J.Immunol. 177:8365. (FC) PubMed
  12. Grégoire C, et al. 1991. Proc. Natl. Acad. Sci USA 88:8077.
Product Citations
  1. Luo X, et al. 2020. Front Immunol. 11:623. PubMed
  2. Mason HD, et al. 2021. JCI Insight. 6:e149229. PubMed
  3. Delacher M, et al. 2021. Immunity. 54(4):702-720.e17. PubMed
  4. Piper CJM, et al. 2020. Cell Reports. 29(7):1878-1892.e7.. PubMed
  5. Nagai Y, et al. 2019. Front Immunol. 10:174. PubMed
  6. Sugimoto C, et al. 2022. Elife. 11:. PubMed
  7. Koren N, et al. 2021. Cell Host Microbe. 29(2):197-209.e5. PubMed
  8. Wei SC, et al. 2020. Cancer Discov. . PubMed
  9. Wang Y, et al. 2021. Cell Rep. 35:108948. PubMed
  10. Casulli J, et al. 2019. Nat Commun. 10:2121. PubMed
  11. Liu S, et al. 2020. Cell Host & Microbe. 26(6):779-794.e8.. PubMed
  12. Melo-Silva CR, et al. 2021. PLOS Pathogens. 17(5):e1009593. PubMed
  13. Rosser EC, et al. 2020. Cell Metabolism. 31(4):837-851. PubMed
  14. Baja?a S, et al. 2022. iScience. 25:103732. PubMed
  15. Corrado M, et al. 2020. Cell Metab. 32:981. PubMed
  16. Rezende RM, et al. 2019. J Immunol. 203:2621. PubMed
  17. Yun JH, et al. 2021. JCI Insight. 6:. PubMed
  18. Spath S, et al. 2022. iScience. 25:104998. PubMed
  19. Trindade BC, et al. 2021. Immunity. 54:2273. PubMed
RRID
AB_2629563 (BioLegend Cat. No. 109241)

Antigen Details

Structure
Ig superfamily, CD3/TCR complex with CD3 and TCR α subunit
Distribution

Majority of T cells and thymocytes (correlated to differentiation)

Function
Antigen recognition, T cell activation
Ligand/Receptor
Peptide bound-MHC class I and II
Antigen References

1. Davis MM, et al. 1998. Ann. Rev. Immunol. 16:523.
2. Huppa JB, et al. 2003. Nat. Immunol. 4:749.
3. Kubo R, et al. 1989. J. Immunol. 142:2736.

Gene ID
21577 View all products for this Gene ID
UniProt
View information about TCR beta chain on UniProt.org

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