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首页 > 抗体蛋白 > 抗体
APC anti-mouse TCR β chain Antibody
产品名称：
APC anti-mouse TCR β chain Antibody
产品类别：
抗体
产品编号：
109211
产品应用：
109211
[价格]
规格 价格 库存
25µg ￥ 924 1

产品详情

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
Affinity purified TCR from mouse DO-11.10 cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 ?g per 106 cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

H57-597 is a hamster mAb directed to an epitope of the C region of TCR ? chain12. The H57-597 antibody does not cross-react with ?/d TCR-bearing T cells. Immobilized or soluble H57-597 antibody can activate a/? TCR-bearing T cells. Additional reported applications (for the relevant formats) for this antibody include: immunoprecipitation2, in vitro stimulation2,3, in vivo depletion4-6, and immunohistochemical staining of acetone-fixed frozen sections7,8,9. The Ultra-LEAF? purified antibody (Endotoxin <0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. No. 109253-109258).

Application References

(PubMed link indicates BioLegend citation)
  1. Gascoigne NJ. 1990. J. Biol. Chem. 265:9296.
  2. Kruisbeek A, et al. 1991. In Current Protocols in Immunology. pp. 3.12.1. (Costim IP)
  3. Davenport C, et al. 1995. J. Immunol. 155:3742. (Costim)
  4. Drobyski W, et al. 1996. Blood 87:5355. (Deplete)
  5. Kummer U, et al. 2001. Immunol. Lett. 75:153. (Deplete)
  6. van der Heyde HC, et al. 1995. J. Immunol. 154:3985. (Deplete)
  7. Tomita K, et al. 1999. Genes Dev. 13:1203. (IHC)
  8. Podd BS, et al. 2006. J. Immunol. 176:6532. (IHC)
  9. Ponomarev ED, et al. 2007. J. Immunol. 178:39. (IHC)
  10. Chappaz S, et al. 2007. Blood doi:10.1182/blood-2007-02-074245. (FC) PubMed
  11. Tsukumo S, et al. 2006. J.Immunol. 177:8365. (FC) PubMed
  12. Grégoire C, et al. 1991. Proc. Natl. Acad. Sci USA 88:8077.
Product Citations
  1. Kisielow J, et al. 2019. Nat Immunol. 1.286111111. PubMed
  2. Grigsby SM, et al. 2021. Cancers (Basel). 13:. PubMed
  3. Chappaz S, et al. 2021. Cell Reports. 36(3):109430. PubMed
  4. Ferrari de Andrade L, et al. 2020. Cancer Immunol Res. 0.867361111. PubMed
  5. Marco Barros R, et al. 2016. Cell. 167: 203-218. PubMed
  6. Nesterenko PA, et al. 2021. Cell Rep. 37:110167. PubMed
  7. Lee H, et al. 2020. Cell Metabolism. 31(4):822-836. PubMed
  8. Baranek T, et al. 2020. Cell Reports. 32(10):108116. PubMed
  9. Andrews D, et al. 2008. J Virol. 82:4931. PubMed
  10. Ma KY, et al. 2021. Nat Immunol. 22:1590. PubMed
  11. Isoda T et al. 2017. Cell. 171(1):103-119 . PubMed
  12. Schwartz DM et al. 2019. Immunity. 50(1):106-120 . PubMed
  13. Chen L, et al. 2018. Immunology. 155:123. PubMed
  14. Liu X, et al. 2021. eLife. 0.416666666666667. PubMed
  15. Porsche CE, et al. 2021. JCI Insight. 6:. PubMed
  16. Runge EM, et al. 2020. J Neuroinflammation. 17:121. PubMed
  17. Levine LS, et al. 2021. Immunity. 54(4):829-844.e5. PubMed
  18. Bunn P, et al. 2014. J Immunol. 192:3709. PubMed
  19. Mahadevan NR, et al. 2021. Cancer Discov. 11:1952. PubMed
  20. Yue X, et al. 2019. Nat Commun. 10:2011. PubMed
  21. Hanasoge Somasundara AV, et al. 2021. Cell Rep. 37:110099. PubMed
  22. Knizkova D, et al. 2022. Nat Immunol. 23:1644. PubMed
  23. Mallis R, et al. 2015. Proc Natl Acad Sci U S A. 112: 8373 - 8378. PubMed
  24. Horkova V, et al. 2020. Cell Reports. 30(5):1504-1514.e7.. PubMed
  25. Kondo M, et al. 2016. J Immunol. 196: 563 - 572. PubMed
  26. Frost JN, et al. 2021. Med (N Y). 2:164. PubMed
  27. Georgoudaki A, et al. 2016. Cell Rep. 15: 2000-2011. PubMed
  28. Shiozawa S, et al. 2022. iScience. 25:103537. PubMed
  29. Muri J, et al. 2020. eLife. 9:e53627.. PubMed
  30. Chuang YT, et al. 2019. J Allergy Clin Immunol. 143:565. PubMed
  31. Metidji A et al. 2018. Immunity. 49(2):353-362 . PubMed
  32. Amezcua Vesely MC, et al. 2020. Cell. 178(5):1176-1188.e15.. PubMed
  33. Baja?a S, et al. 2022. iScience. 25:103732. PubMed
  34. Müller TR, et al. 2021. Cell Rep Med. 2:100374. PubMed
  35. Kiss M, et al. 2020. Cancer Immunol Res. 9:309. PubMed
  36. Sparber F, et al. 2019. Cell Host Microbe. 25:389. PubMed
  37. Tsyklauri O, et al. 2021. EMBO Rep. 22:e50785. PubMed
  38. Baptista M, et al. 2016. Nat Commun. 7:12175. PubMed
  39. Zhu M, et al. 2012. J Biol Chem. 287:8135. PubMed
  40. Hirota K et al. 2018. Immunity. 48(6):1220-1232 . PubMed
  41. Kanuma T, et al. 2017. The Journal of Immunology. 10.4049/jimmunol.1600731. PubMed
  42. Jaeger N, et al. 2020. Cell Rep. 33:108331. PubMed
  43. Heyde A, et al. 2021. Cell. 184(5):1348-1361.e22. PubMed
  44. Preece R, et al. 2020. Mol Ther Methods Clin Dev. 0.895138889. PubMed
  45. Andrews D, et al. 2010. J Exp Med. 207:1333. PubMed
  46. Zhang B, et al. 2021. Nature. 599:471. PubMed
  47. Meng Q, et al. 2021. J Immunother Cancer. 9:. PubMed
  48. Hsu HP, et al. 2021. J Biol Chem. 296:100419. PubMed
  49. Szeto C, et al. 2022. Nat Commun. 13:4951. PubMed
  50. Ley S 2009. J Immunol. 183:865. PubMed
  51. Omenetti S, et al. 2019. Immunity. 51:77. PubMed
RRID
AB_313434 (BioLegend Cat. No. 109211) AB_313435 (BioLegend Cat. No. 109212)

Antigen Details

Structure
Ig superfamily, CD3/TCR complex with CD3 and TCR α subunit
Distribution

Majority of T cells and thymocytes (correlated to differentiation)

Function
Antigen recognition, T cell activation
Ligand/Receptor
Peptide bound-MHC class I and II
Antigen References

1. Davis MM, et al. 1998. Ann. Rev. Immunol. 16:523.
2. Huppa JB, et al. 2003. Nat. Immunol. 4:749.
3. Kubo R, et al. 1989. J. Immunol. 142:2736.

Gene ID
21577 View all products for this Gene ID
UniProt
View information about TCR beta chain on UniProt.org

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