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首页 > 抗体蛋白 > 抗体
Purified anti-human CD107a (LAMP-1) Antibody
产品名称：
Purified anti-human CD107a (LAMP-1) Antibody
产品类别：
抗体
产品编号：
328601
产品应用：
328601
[价格]
规格 价格 库存
25µg ￥ 708 1

产品详情

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Baboon, Chimpanzee, Cynomolgus, Pigtailed Macaque, Rhesus
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human adult adherent peripheral blood cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
ICC, WB, IHC-P - Verified
IP - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 ?g per million cells in 100 ?l volume. For Western blotting, the suggested use of this reagent is 1.0?- 5.0??g per ml. For immunocytochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 5.0?- 10 μg per ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: Western blotting8, immunohistochemical staining2, immunofluorescence5,7, and immunoprecipitation5.

This antibody is specific to human LAMP-1. Positive control: Hela cells; LAMP-1 molecular weight appears to be at ~110 kDa on the gel due to high glycosylation.

Application References

(PubMed link indicates BioLegend citation)
  1. Misse D, et al. 1999. Blood 93:2454.
  2. Furuta K, et al. 2001. Am. J. Pathol. 159:449. (IHC)
  3. Watanabe A, et al. 2011. J. Biol. Chem. 286:10702. PubMed
  4. Baron Gaillard CL, et al. 2011. Mol. Cell. Biol. 22:5459. PubMed
  5. Hauck CR and Meyer TF. 1997. FEBS Lett. 405:86. (IF, IP)
  6. De Keersmaecker B, et al. 2012. J. Virol. 86:9351. PubMed
  7. Knodler LA, et al. 2010. P. Natl. Acad. Sci. USA. 107:17733. (IF)
  8. Oh J, et al. 2000. Hum. Mol. Genet. 9:375. (WB)
  9. Salio M, et al. 2013 PNAS. 110:4753. PubMed
Product Citations
  1. Lin CN, et al. 2021. Mol Ther Nucleic Acids. 23:757. PubMed
  2. Aoki T, et al. 2020. Cancer Sci. 111:2223. PubMed
  3. Gaillard C, et al. 2011. Mol Biol Cell. 4.075694444. PubMed
  4. Holder KA, et al. 2021. Clin Transl Immunology. 10:e1348. PubMed
  5. Escrevente C, et al. 2021. J Cell Sci. :. PubMed
  6. Zhang Y, et al. 2022. Exp Hematol Oncol. 11:15. PubMed
  7. Kondo H, et al. 2022. Front Immunol. 13:836923. PubMed
  8. Baranov M, et al. 2016. Cell Rep. 17:1518-1531. PubMed
  9. Baranov MV, et al. 2022. Biophys Rep (N Y). 2:100069. PubMed
  10. Salio M, et al. 2013. Proc Natl Acad Sci U S A. 110:4753. PubMed
  11. Amaya C, et al. 2021. J Biol Chem. 297:100937. PubMed
  12. Shimizu S, et al. 2021. Sci Rep. 11:5199. PubMed
  13. Speir M,et al. 2017. Sci Rep.. 10.1038/s41598-017-14690-5. PubMed
  14. Liu X, et al. 2021. Nat Commun. 12:4427. PubMed
  15. Kabanova A, et al. 2016. Cell Rep. S2211-1247: 30219-4. PubMed
  16. Watanabe A, et al. 2011. J Biol Chem. 286:10702. PubMed
  17. Baranov MV, et al. 2018. iScience. 11:160. PubMed
  18. Watanabe H, et al. 2021. Eneuro. :8. PubMed
  19. Sonnenschein HA, et al. 2018. FEBS Open Bio. 14:e1007334. PubMed
  20. Zhang M, et al. 2022. Front Oncol. 12:828041. PubMed
  21. Carlsten M, et al. 2019. Oncoimmunology. 8:e1534664. PubMed
  22. Mendler A, et al. 2020. Clin Exp Immunol. 200:199. PubMed
RRID
AB_1134260 (BioLegend Cat. No. 328601) AB_1134259 (BioLegend Cat. No. 328602)

Antigen Details

Structure
LAMP-1 is a 417 amino acid protein with a molecular mass of 45 kD.
Distribution

Macrophages, epithelial cells, endothelial cells, some tumor cells; located on the luminal side of lysosomes or on the surface of cell membranes

Function
Protect lysosomal membrane from lysosomal hydrolases, adhesion
Ligand/Receptor
Galaptin
Cell Type
Endothelial cells, Epithelial cells, Macrophages
Biology Area
Cell Biology, Immunology, Neurodegeneration, Neuroscience, Protein Trafficking and Clearance
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Sarafian V, et al. 2006. Arch. Dermatol. Res. 298:7381.
2. Schlossman SF, et al. 1995. Leukocyte Typing V:White Cell Differentiation Antigens. New York:Oxford University Press.
3. Sawada R, et al. 1993. J. Biol. Chem. 268:12675.
4. Chen JW, et al. 1988. J. Biol. Chem. 263:8754.
5. Chen JW, et al. 1986. Biochem. Soc. Symp. 51:97112.

Gene ID
3916 View all products for this Gene ID
UniProt
View information about CD107a on UniProt.org

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