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首页 > 抗体蛋白 > 抗体
FITC anti-human CD107a (LAMP-1) Antibody
产品名称：
FITC anti-human CD107a (LAMP-1) Antibody
产品类别：
抗体
产品编号：
328605
产品应用：
328605
[价格]
规格 价格 库存
25tests ￥ 1176 1

产品详情

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Baboon, Chimpanzee, Cynomolgus, Pigtailed Macaque, Rhesus
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human adult adherent peripheral blood cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser
Blue Laser (488 nm)
Application Notes

Additional reported applications (for the relevant formats) include: Western blotting8, immunohistochemical staining2, immunofluorescence5,7, and immunoprecipitation5.

This antibody is specific to human LAMP-1. Positive control: Hela cells; LAMP-1 molecular weight appears to be at ~110 kDa on the gel due to high glycosylation.

Application References

(PubMed link indicates BioLegend citation)
  1. Misse D, et al. 1999. Blood 93:2454.
  2. Furuta K, et al. 2001. Am. J. Pathol. 159:449. (IHC)
  3. Watanabe A, et al. 2011. J. Biol. Chem. 286:10702. PubMed
  4. Baron Gaillard CL, et al. 2011. Mol. Cell. Biol. 22:5459. PubMed
  5. Hauck CR and Meyer TF. 1997. FEBS Lett. 405:86. (IF, IP)
  6. De Keersmaecker B, et al. 2012. J. Virol. 86:9351. PubMed
  7. Knodler LA, et al. 2010. P. Natl. Acad. Sci. USA. 107:17733. (IF)
  8. Oh J, et al. 2000. Hum. Mol. Genet. 9:375. (WB)
  9. Salio M, et al. 2013 PNAS. 110:4753. PubMed
Product Citations
  1. Khan A, et al. 2015. J Virol. 89:3776. PubMed
  2. Xu H, et al. 2019. Cell Stem Cell. 24:566. PubMed
  3. Jonescheit H, et al. 2020. Cells. :9. PubMed
  4. Bilich T, et al. 2021. Cancer Discov. 11:1982. PubMed
  5. Myers JA, et al. 2022. JCI Insight. :. PubMed
  6. Bawazir M, et al. 2022. Front Immunol. 13:1033794. PubMed
  7. Nguyen MAT, et al. 2020. Immunohorizons. 0.465277778. PubMed
  8. Bauer J, et al. 2022. Nat Commun. 13:6401. PubMed
  9. Yu H, et al. 2021. Mol Ther Oncolytics. 21:158. PubMed
  10. Hendricks D, et al. 2014. J Immunol. 192:4492. PubMed
  11. Guiliani E, et al. 2017. Immunol Lett. 10.1016/j.imlet.2017.08.014. PubMed
  12. van der Ploeg K, et al. 2022. Cell Rep Med. 3:100640. PubMed
  13. Cribbs AP, et al. 2021. Front Immunol. 12:626255. PubMed
  14. Bilich T, et al. 2021. Science Translational Medicine. 13(590):. PubMed
  15. Bilich T, et al. 2020. Blood Cancer J. 10:24. PubMed
  16. Bertulli C, et al. 2020. Int J Mol Sci. 21:. PubMed
  17. Heitmann JS, et al. 2021. Nature. Online ahead of print. PubMed
  18. Dockry E, et al. 2018. Oncoimmunology. 7:e1428156. PubMed
  19. Tai Y, et al. 2012. Blood. 119:2074. PubMed
  20. Ni J, et al. 2020. Immunity. 52(6):1075-1087.e8. PubMed
  21. Zhang X, et al. 2021. Front Immunol. 12:602492. PubMed
  22. Davis Z, et al. 2016. PLoS Pathog. 12: 1005421. PubMed
  23. Schlecker E, et al. 2014. Cancer Res. 74:3429. PubMed
  24. Ferry GM, et al. 2022. Front Immunol. 13:863155. PubMed
  25. Burel J, et al. 2016. PLoS Negl Trop Dis. 10:e0005031. PubMed
  26. Lettau M, et al. 2018. Int Immunol. 30:215. PubMed
  27. Khan AA, et al. 2018. J Virol. 92:e00535. PubMed
  28. Pahl JHW, et al. 2018. Cancer Immunol Res. 0.609027778. PubMed
  29. Felices M, et al. 2018. JCI Insight. 3. PubMed
  30. Srivastava R, et al. 2015. J Immunol. 194:2232. PubMed
  31. Kwant-Mitchell A, et al. 2009. PLoS One. 4:e8379. PubMed
  32. Bennstein SB, et al. 2020. eLife. 9:e55232.. PubMed
RRID
AB_1186058 (BioLegend Cat. No. 328605) AB_1186036 (BioLegend Cat. No. 328606)

Antigen Details

Structure
LAMP-1 is a 417 amino acid protein with a molecular mass of 45 kD.
Distribution

Macrophages, epithelial cells, endothelial cells, some tumor cells; located on the luminal side of lysosomes or on the surface of cell membranes

Function
Protect lysosomal membrane from lysosomal hydrolases, adhesion
Ligand/Receptor
Galaptin
Cell Type
Endothelial cells, Epithelial cells, Macrophages
Biology Area
Cell Biology, Immunology, Neurodegeneration, Neuroscience, Protein Trafficking and Clearance
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Sarafian V, et al. 2006. Arch. Dermatol. Res. 298:7381.
2. Schlossman SF, et al. 1995. Leukocyte Typing V:White Cell Differentiation Antigens. New York:Oxford University Press.
3. Sawada R, et al. 1993. J. Biol. Chem. 268:12675.
4. Chen JW, et al. 1988. J. Biol. Chem. 263:8754.
5. Chen JW, et al. 1986. Biochem. Soc. Symp. 51:97112.

Gene ID
3916 View all products for this Gene ID
UniProt
View information about CD107a on UniProt.org

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