PE anti-mouse CD85k (gp49 Receptor) Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25µg	￥ 1548	1

Product Details

Verified Reactivity

Mouse

Antibody Type

Monoclonal

Host Species

Armenian Hamster

Immunogen

gp49B-Fc fusion protein

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.

Concentration

0.2 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser

Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)

Application Notes

Clone H1.1 recognizes both gp49A and gp49B. Additional reported applications (for the relevant formats) include in vitro activation of gp49B to inhibit cytokine production.? The LEAF? or Ultra-LEAF? purified antibody is recommended for functional assays (contact our custom solutions team).

Application References (PubMed link indicates BioLegend citation)

Wang LL, et al. 2000. J. Immunol. 164:5215. (Activ)

Product Citations

Hudson WH, et al. 2020. Immunity. 51(6):1043-1058.e4.. PubMed
Li Q, et al. 2019. Neuron. 101:207. PubMed
Mitsune A, et al. 2021. Respir Res. 22:232. PubMed
Mansouri S, et al. 2020. Mucosal Immunol. 0.954861111. PubMed
Matsumura T, et al. 2022. Nat Commun. 13:7064. PubMed
Vogel A, et al. 2022. Cell Rep. 38:110420. PubMed

RRID

AB_2561653 (BioLegend Cat. No. 144903) AB_2561654 (BioLegend Cat. No. 144904)

Antigen Details

Structure: Type I membrane protein belonging to Ig superfamily
Distribution: Myeloid cells, activated NK cells
Function: Inhibitory activity mediated by ITIM motif
Interaction: SHP-1 and SHP-2
Ligand/Receptor: Integrin α_vβ₃, collagen
Cell Type: NK cells, Dendritic cells
Biology Area: Immunology, Innate Immunity
Molecular Family: CD Molecules
Antigen References: 1. Castells, MC, et al. 1994. J. Biol. Chem. 269:8393.
2. Katz HR, et al. 1996. P. Natl. Acad. Sci. USA 93:10809.
3. Kuroiwa A, et al. 1998. J. Biol. Chem. 273:1070.
4. Wang LL, et al. 2000. J. Immunol. 164:5215.
5. Jiang L, et al. 2009. Eur. J. Immunol. 39:1167.
Gene ID: 14728 View all products for this Gene ID
UniProt: View information about CD85k on UniProt.org

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