Alexa Fluor® 647 anti-mouse CD85k (gp49 Recept-上海雅吉生物科技有限公司

规格	价格	库存
25µg	￥ 1764	1

Product Details

Verified Reactivity

Mouse

Antibody Type

Monoclonal

Host Species

Armenian Hamster

Immunogen

gp49B-Fc fusion protein

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography and conjugated with Alexa Fluor? 647 under optimal conditions.

Concentration

0.5 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

* Alexa Fluor? 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.

Alexa Fluor? and Pacific Blue? are trademarks of Life Technologies Corporation.

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Excitation Laser

Red Laser (633 nm)

Application Notes

Clone H1.1 recognizes both gp49A and gp49B. Additional reported applications (for the relevant formats) include in vitro activation of gp49B to inhibit cytokine production.? The LEAF? or Ultra-LEAF? purified antibody is recommended for functional assays (contact our custom solutions team).

Application References (PubMed link indicates BioLegend citation)

Wang LL, et al. 2000. J. Immunol. 164:5215. (Activ)

Product Citations

Kretzschmar F, et al. 2021. Biology (Basel). 10:. PubMed
Plenter RJ, et al. 2018. Cell Immunol. 332:101. PubMed
Su R, et al. 2020. Cancer Cell. 38(1):79-96.e11. PubMed
Van Gool F, et al. 2019. Immunity. 50:362. PubMed
Lee HN, et al. 2022. JCI Insight. 7:. PubMed

RRID

AB_2562043 (BioLegend Cat. No. 144905) AB_2562044 (BioLegend Cat. No. 144906)

Antigen Details

Structure: Type I membrane protein belonging to Ig superfamily
Distribution: Myeloid cells, activated NK cells
Function: Inhibitory activity mediated by ITIM motif
Interaction: SHP-1 and SHP-2
Ligand/Receptor: Integrin α_vβ₃, collagen
Cell Type: NK cells, Dendritic cells
Biology Area: Immunology, Innate Immunity
Molecular Family: CD Molecules
Antigen References: 1. Castells, MC, et al. 1994. J. Biol. Chem. 269:8393.
2. Katz HR, et al. 1996. P. Natl. Acad. Sci. USA 93:10809.
3. Kuroiwa A, et al. 1998. J. Biol. Chem. 273:1070.
4. Wang LL, et al. 2000. J. Immunol. 164:5215.
5. Jiang L, et al. 2009. Eur. J. Immunol. 39:1167.
Gene ID: 14728 View all products for this Gene ID
UniProt: View information about CD85k on UniProt.org

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