PerCP/Cyanine5.5 anti-human/mouse Integrin β7-上海雅吉生物科技有限公司

规格	价格	库存
25tests	￥ 1764	1

Product Details

Verified Reactivity

Human, Mouse, Cynomolgus, Rhesus

Reported Reactivity

African Green, Baboon, Chimpanzee

Antibody Type

Monoclonal

Host Species

Rat

Immunogen

TK1 cells

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)

Preparation

The antibody was purified by affinity chromatography and conjugated with PerCP/Cyanine5.5 under optimal conditions.

Concentration

Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

* PerCP/Cyanine5.5 has a maximum absorption of 482 nm and a maximum emission of 690 nm.

Excitation Laser

Blue Laser (488 nm)

Application Notes

The FIB504 antibody has been reported to react with mouse and human ?7 integrin and to block ?7 integrin-mediated cell adhesion in in vitro and in vivo studies. Additional reported applications (for the relevant formats) include: blocking of cell adhesion^1,3,4. The Ultra-LEAF? purified FIB504 antibody (Endotoxin < 0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. No. 321233-321238).

Additional Product Notes

BioLegend is in the process of converting the name PerCP/Cy5.5 to PerCP/Cyanine5.5. The dye molecule remains the same, so you should expect the same quality and performance from our PerCP/Cyanine5.5 products. Contact Technical Service if you have any questions.

Application References (PubMed link indicates BioLegend citation)

Andrew DP, et al. 1994. J. Immunol. 153:3847. (Block)
Berlin C, et al. 1993. Cell 74:185.
Rott LS, et al. 1996. J. Immunol. 156:3727. (Block)
Rivera-Nieves J, et al. 2005. J. Immunol. 174:2343. (Block)
Ohmori K, et al. 2009. J. Immunol. 182:2835. PubMed
Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)

Product Citations

FitzPatrick MEB, et al. 2021. Cell Rep. 34:108661. PubMed

RRID

AB_2561792 (BioLegend Cat. No. 321219) AB_2561793 (BioLegend Cat. No. 321220)

Antigen Details

Structure: Integrin family, Ig superfamily, 130 kD, heterodimer with CD49d or CD103
Distribution: CD49d/β7: majority of lymphocytes, thymocyte subset, and some bone marrow progenitors; CD103/β7: intestinal intraepithelial lymphocytes (IEL), dendritic epidermal T cells, subset of CD8 T cells in lymph nodes
Function: Lymphocyte adhesion, hematopoietic progenitor cells migration
Ligand/Receptor: CD49d/β7: VCAM-1 (CD106), MAdCAM-1 and fibronectin; CD103/β7: E-cadherin
Cell Type: Dendritic cells, Hematopoietic stem and progenitors, Lymphocytes, T cells, Thymocytes, Tregs
Biology Area: Cell Biology, Immunology, Neuroscience, Synaptic Biology
Molecular Family: Adhesion Molecules, CD Molecules
Antigen References: 1. Andrew DP, et al. 1994. J. Immunol. 153:3847.
2. Picarella D, et al. 1997. J. Immunol. 158:2099.
3. Lefrancois L, et al. 1994. Eur. J. Immunol. 24:635
4. Cepek KL, et al. 1994. Nautre 372:190.
Gene ID: 16421 View all products for this Gene ID 3695 View all products for this Gene ID
UniProt: View information about Integrin beta7 on UniProt.org

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