APC/Fire™ 750 anti-human/mouse Integrin &bet
- 产品名称：
- APC/Fire™ 750 anti-human/mouse Integrin &bet
- 产品类别：
- 抗体
- 产品编号：
- 321223
- 产品应用：
- 321223
[价格]
| 规格 |
价格 |
库存 |
| 25tests |
￥ 1692 |
1 |
- Verified Reactivity
- Human, Mouse, Cynomolgus, Rhesus
- Reported Reactivity
- African Green, Baboon, Chimpanzee
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- TK1 cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC/Fire? 750 under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC -?Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
* APC/Fire? 750 has a maximum excitation of 650 nm and a maximum emission of 787 nm.
- Excitation Laser
- Red Laser (633 nm)
- Application Notes
The FIB504 antibody has been reported to react with mouse and human ?7 integrin and to block ?7 integrin-mediated cell adhesion in in vitro and in vivo studies. Additional reported applications (for the relevant formats) include: blocking of cell adhesion1,3,4. The Ultra-LEAF? purified FIB504 antibody (Endotoxin < 0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. No. 321233-321238).
- Application References
(PubMed link indicates BioLegend citation) -
- Andrew DP, et al. 1994. J. Immunol. 153:3847. (Block)
- Berlin C, et al. 1993. Cell 74:185.
- Rott LS, et al. 1996. J. Immunol. 156:3727. (Block)
- Rivera-Nieves J, et al. 2005. J. Immunol. 174:2343. (Block)
- Ohmori K, et al. 2009. J. Immunol. 182:2835. PubMed
- Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
- Product Citations
-
- Bugajev V, et al. 2021. Front Immunol. 11:591975. PubMed
- RRID
- AB_2715980 (BioLegend Cat. No. 321223) AB_2715981 (BioLegend Cat. No. 321224)
- Structure
- Integrin family, Ig superfamily, 130 kD, heterodimer with CD49d or CD103
- Distribution
-
CD49d/β7: majority of lymphocytes, thymocyte subset, and some bone marrow progenitors; CD103/β7: intestinal intraepithelial lymphocytes (IEL), dendritic epidermal T cells, subset of CD8 T cells in lymph nodes
- Function
- Lymphocyte adhesion, hematopoietic progenitor cells migration
- Ligand/Receptor
- CD49d/β7: VCAM-1 (CD106), MAdCAM-1 and fibronectin; CD103/β7: E-cadherin
- Cell Type
- Dendritic cells, Hematopoietic stem and progenitors, Lymphocytes, T cells, Thymocytes, Tregs
- Biology Area
- Cell Biology, Immunology, Neuroscience, Synaptic Biology
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
-
1. Andrew DP, et al. 1994. J. Immunol. 153:3847.
2. Picarella D, et al. 1997. J. Immunol. 158:2099.
3. Lefrancois L, et al. 1994. Eur. J. Immunol. 24:635
4. Cepek KL, et al. 1994. Nautre 372:190.
- Gene ID
- 16421 View all products for this Gene ID 3695 View all products for this Gene ID
- UniProt
- View information about Integrin beta7 on UniProt.org
