PE anti-human CD366 (Tim-3) Antibody
- 产品名称：
- PE anti-human CD366 (Tim-3) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 345005
- 产品应用：
- 345005
[价格]
| 规格 |
价格 |
库存 |
| 25tests |
￥ 1836 |
1 |
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human Tim-3 fusion protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
Additional reported applications (for relevant formats of this clone) include: costimulation1 (clone 2E2 has been shown to enhance T-cell receptor mediated activation and cytokine secretion) and blocking2,3.
- Application References
(PubMed link indicates BioLegend citation) -
- Hastings WD, et al. 2009. Eur. J. Immunol. 39:2492. (Costim)
- Jones RB, et al. 2008. J. Exp. Med. 205:2763. (Block)
- Klibi J, et al 2009. Blood 113:1957. (FC, Block)
- Product Citations
-
- Fang L, et al. 2013. Neuro Oncology. 15:1479. PubMed
- Jung IY, et al. 2022. Sci Transl Med. 14:eabn7336. PubMed
- Poonia B, Pauza C 2014. PLoS One. 9:88884. PubMed
- Yang H, et al. 2019. Mol Metab. 23:24. PubMed
- Roberts A, et al. 2021. Sci Rep. 11:4030. PubMed
- Ho T, et al. 2016. Blood. 128: 1671 - 1678. PubMed
- Wang H, et al. 2022. Front Immunol. 13:852436. PubMed
- Wei F, et al. 2013. Proc Natl Acad Sci U S A. 110:2480. PubMed
- Wang S, et al. 2021. Exp Ther Med. 21:37. PubMed
- de Boer B et al. 2018. Cancer cell. 34(4):674-689 . PubMed
- Sun L, et al. 2020. J Diabetes Res. 2020:2583257. PubMed
- Su W, et al. 2022. Front Immunol. 13:952338. PubMed
- Cai D, et al. 2021. Front Mol Biosci. 8:686803. PubMed
- Ping Y, et al. 2020. Front Cell Dev Biol. 0.890972222. PubMed
- Andersch L, et al. 2019. BMC Cancer. 19:895. PubMed
- Zhang Y, et al. 2012. J Leukoc Biol. 91:189. PubMed
- Srivastava S, et al. 2019. Cancer Cell. 35:489. PubMed
- Houtsma R, et al. 2021. STAR Protoc. 2:100864. PubMed
- Bhattacharya P, et al. 2020. Elife. 9:00. PubMed
- Fromentin R, et al. 2016. PLoS Pathog. 12: 1005761. PubMed
- Ho JY, et al. 2021. Mol Ther Methods Clin Dev. 21:237. PubMed
- Jin C, et al. 2016. EMBO Mol Med. 8: 702 - 711. PubMed
- Barresi V, et al. 2020. J Clin Med. 9:00. PubMed
- Srivastava S, et al. 2020. Cancer Cell. 39(2):193-208.e10. PubMed
- Gorris MAJ, et al. 2018. J Immunol. 200:347. PubMed
- Finney OC, et al. 2019. J Clin Invest. 130:. PubMed
- Lake CM, et al. 2021. Cell Death Dis. 12:400. PubMed
- RRID
- AB_1877236 (BioLegend Cat. No. 345005) AB_2116576 (BioLegend Cat. No. 345006)
- Structure
- Transmembrane protein containing immunoglobulin domain and mucin-like domain; can exist as a soluble form lacking mucin and transmembrane domains
- Distribution
-
Activated T cells, preferentially on Th1 cells, monocytes, dendritic cells
- Function
- Plays a role in regulating macrophage activation, T cell apoptosis and immune tolerance
- Ligand/Receptor
- Galectin-9
- Cell Type
- Dendritic cells, Monocytes, T cells, Th1, Tregs
- Biology Area
- Immunology, Inhibitory Molecules
- Molecular Family
- CD Molecules, Immune Checkpoint Receptors
- Antigen References
-
1. Hafler DA and Kuchroo V. 2008. J. Exp. Med. 205:2699.
2. Zhu C, et al. 2005. Nat. Immunol. 6:1245.
3. Wang F, et al. 2009. Immunobiology 214:342.
- Gene ID
- 84868 View all products for this Gene ID
- UniProt
- View information about CD366 on UniProt.org
