Purified anti-TIMP-2 Antibody
- 产品名称：
- Purified anti-TIMP-2 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 635401
- 产品应用：
- 635401
- Verified Reactivity
- Human, Mouse, Rabbit, Chicken, Zebrafish, Swine (Pig, Porcine)
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Ovalbumin-conjugated synthetic Peptide DSGNDIYGNPI
- Formulation
- This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide at 0.5 mg/ml.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, store undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
IHC-P, ELISA - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, suggested working dilution(s): Use 5-10 ?g per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
(PubMed link indicates BioLegend citation) -
- Murray G et al. 1998. Gut. 43:791.
- Fromique O, et al. 2008. J. Biol. Chem. 283:30549. PubMed
- Product Citations
-
- Fromigué O, et al. 2008. J Biol Chem. 283:30549. PubMed
- RRID
- AB_2287490 (BioLegend Cat. No. 635401) AB_2204826 (BioLegend Cat. No. 635402)
- Structure
- Belongs to the protease inhibitor I35 (TIMP) family. Contains 1 NTR domain, predicted molecular weight 24 kD.
- Distribution
-
Extracellular
- Function
- TIMP-2 binds to the surface of human endothelial cells through interaction with the integrin α3β1, and abrogates angiogenic factor induced endothelial cell proliferation in vitro and angiogenesis in vivo independent of MMP inhibition.
- Interaction
- MMP2, MMP8, MMP14, CD49C
- Biology Area
- Angiogenesis, Apoptosis/Tumor Suppressors/Cell Death, Cell Adhesion, Cell Biology
- Molecular Family
- Enzymes and Regulators
- Antigen References
-
1. Stetler-Stevenson, et al. 1989. J. Biol. Chem. 264:17374
- Gene ID
- 7077 View all products for this Gene ID
- UniProt
- View information about TIMP-2 on UniProt.org
