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首页 > 抗体蛋白 > 抗体
Purified anti-human CD279 (PD-1) Antibody
产品名称：
Purified anti-human CD279 (PD-1) Antibody
产品类别：
抗体
产品编号：
329902
产品应用：
329902
[价格]
规格 价格 库存
100µg ￥ 1068 1

产品详情

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Baboon, Chimpanzee, Common Marmoset, Cynomolgus, Rhesus, Squirrel Monkey
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Block, IHC-F - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: blocking of ligand binding1-3,?immunohistochemical staining of paraformaldehyde fixed frozen sections13, and spatial biology (IBEX)15,16. The LEAF? purified antibody (Endotoxin <0.1 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. No. 329911 and 329912). For highly sensitive assays, we recommend Ultra-LEAF? purified antibody (Cat. No. 329926) with a lower endotoxin limit than standard LEAF? purified antibodies (Endotoxin <0.01 EU/?g).

Application References

(PubMed link indicates BioLegend citation)
  1. Dorfman DM, et al. 2006 Am. J. Surg. Pathol. 30:802. (FA)
  2. Radziewicz H, et al. 2007. J. Virol. 81:2545. (FA)
  3. Velu V, et al. 2007. J. Virol. 81:5819. (FA)
  4. Zahn RC, et al. 2008. J. Virol. 82:11577. PubMed
  5. Chang WS, et al. 2008. J. Immunol. 181:6707. (FC) PubMed
  6. Nakamoto N, et al. 2009. PLoS Pathog. 5:e1000313. (FA)
  7. Jones RB, et al. 2009. J. Virol. 83:8722. (FC) PubMed
  8. Vojnov L, et al. 2010. J. Virol. 84:753. (FC) PubMed
  9. Radziewicz H, et al. 2010. J. Immunol. 184:2410. (FC) PubMed
  10. Monteriro P, et al. 2011. J. Immunol. 186:4618. PubMed
  11. Conrad J, et al. 2011. J. Immunol. 186:6871. PubMed
  12. Salisch NC, et al. 2010. J. Immunol. 184:476. (Rhesus reactivity)
  13. Li H and Pauza CD. 2015. Eur. J. Immunol. 45:298. (IHC)
  14. Peterson VM, et al. 2017. Nat. Biotechnol. 35:936. (PG)
  15. Radtke AJ,?et al. 2020.?Proc Natl Acad Sci USA. 117:33455-33465. (SB)?PubMed
  16. Radtke AJ,?et al. 2022.?Nat Protoc. 17:378-401. (SB)?PubMed
Product Citations
  1. Dhariwala MO, et al. 2020. Cell Rep Med. 1:100132. PubMed
  2. Zheng G, et al. 2021. Signal Transduct Target Ther. 6:236. PubMed
  3. Gernoux G, et al. 2020. Mol Ther. 28:747. PubMed
  4. Yonemitsu K, et al. 2022. Sci Rep. 12:12007. PubMed
  5. Wagner J et al. 2019. Cell. 177(5):1330-1345 . PubMed
  6. Tocheva AS, et al. 2020. J Biol Chem. 295:18036. PubMed
  7. Lu X, et al. 2018. Am J Cancer Res. 8:1564. PubMed
  8. Chakhtoura M, et al. 2021. PLoS Pathog. 17:e1009732. PubMed
  9. Mann ER, et al. 2020. Sci Immunol. :5. PubMed
  10. Kaufmann M, et al. 2021. Med. 2(3):296-312.e8. PubMed
  11. Dean JW, et al. 2020. J Autoimmun. 108:102417. PubMed
  12. Kondo H, et al. 2022. Front Immunol. 13:836923. PubMed
  13. Hsu DC, et al. 2018. Clin Infect Dis. 67:437. PubMed
  14. Liu F, et al. 2020. J Immunother Cancer. 8:. PubMed
  15. O'Boyle KC, et al. 2020. Methods Mol Biol. 2111:1. PubMed
  16. Cobb DA, et al. 2022. J Immunother Cancer. 10:. PubMed
  17. Mirzaei R, et al. 2021. Sci Adv. 7:eabh2148. PubMed
  18. Del Alcazar D, et al. 2019. Cell Rep. 28:3047. PubMed
  19. Tocheva AS, et al. 2020. J Biol Chem. 295:18036. PubMed
  20. Gee MH, et al. 2018. Cell. 172:549. PubMed
  21. Conrad J, et al. 2012. J Virol. 86:4213. PubMed
  22. Muhammad F, et al. 2020. J Autoimmun. 111:102441. PubMed
  23. Macmillan ML, et al. 2021. Blood Adv. 5:1425. PubMed
  24. Zahn R, et al. 2008. J Virol. 82:11577. PubMed
  25. Schwabenland M, et al. 2021. Immunity. . PubMed
  26. Bengsch B et al. 2018. Immunity. 48(5):1029-1045 . PubMed
  27. Stervbo U, et al. 2019. Front Immunol. 0.949305556. PubMed
  28. Anna F, et al. 2021. J Immunother Cancer. 9:. PubMed
  29. Saber MM, et al. 2022. Antibodies (Basel). 11:. PubMed
  30. Kim MH, et al. 2018. Cancer Immunol Res. 0.427083333. PubMed
  31. Conrad J, et al. 2011. J Immunol. 186:6871. PubMed
  32. Monteiro P, et al. 2011. J Immunol. 186:4618. PubMed
  33. Stensland ZC, et al. 2022. iScience. 25:103626. PubMed
  34. Kim A, et al. 2019. J Immunol. 203:1076. PubMed
  35. Lewinsky H, et al. 2018. J Clin Invest. 128:5465. PubMed
  36. Vojnov L, et al. 2010. J Virol. 84:753. PubMed
  37. Tang X, et al. 2020. Sci Adv. 6:eaaz0374. PubMed
  38. Nicholas K, et al. 2015. Cytometry A. 10.1002/cyto.a.22799. PubMed
  39. Enyindah-Asonye G, et al. 2019. Front Immunol. 10:511. PubMed
  40. Lavin Y et al. 2017. Cell. 169(4):750-765 . PubMed
  41. Hwang HJ, et al. 2021. Immun Inflamm Dis. 9:274. PubMed
  42. Chiou SH, et al. 2021. Immunity. 54:586. PubMed
RRID
AB_940488 (BioLegend Cat. No. 329902)

Antigen Details

Structure
Immunoglobulin superfamily
Distribution

Transiently expressed on CD4- CD8- thymocytes; upregulated in thymocytes and splenic T and B lymphocytes; expressed on activated myeloid cells

Ligand/Receptor
B7-H1 (also known as PD-L1) and B7-DC (PD-L2)
Cell Type
B cells, Lymphocytes, T cells, Thymocytes, Tregs
Biology Area
Cancer Biomarkers, Immunology, Inhibitory Molecules
Molecular Family
CD Molecules, Immune Checkpoint Receptors
Gene ID
5133 View all products for this Gene ID
UniProt
View information about CD279 on UniProt.org

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