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APC anti-human CD279 (PD-1) Antibody
产品名称：
APC anti-human CD279 (PD-1) Antibody
产品类别：
抗体
产品编号：
329907
产品应用：
329907
[价格]
规格 价格 库存
25tests ￥ 1788 1

产品详情

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Baboon, Chimpanzee, Common Marmoset, Cynomolgus, Rhesus, Squirrel Monkey
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: blocking of ligand binding1-3,?immunohistochemical staining of paraformaldehyde fixed frozen sections13, and spatial biology (IBEX)15,16. The LEAF? purified antibody (Endotoxin <0.1 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. No. 329911 and 329912). For highly sensitive assays, we recommend Ultra-LEAF? purified antibody (Cat. No. 329926) with a lower endotoxin limit than standard LEAF? purified antibodies (Endotoxin <0.01 EU/?g).

Application References

(PubMed link indicates BioLegend citation)
  1. Dorfman DM, et al. 2006 Am. J. Surg. Pathol. 30:802. (FA)
  2. Radziewicz H, et al. 2007. J. Virol. 81:2545. (FA)
  3. Velu V, et al. 2007. J. Virol. 81:5819. (FA)
  4. Zahn RC, et al. 2008. J. Virol. 82:11577. PubMed
  5. Chang WS, et al. 2008. J. Immunol. 181:6707. (FC) PubMed
  6. Nakamoto N, et al. 2009. PLoS Pathog. 5:e1000313. (FA)
  7. Jones RB, et al. 2009. J. Virol. 83:8722. (FC) PubMed
  8. Vojnov L, et al. 2010. J. Virol. 84:753. (FC) PubMed
  9. Radziewicz H, et al. 2010. J. Immunol. 184:2410. (FC) PubMed
  10. Monteriro P, et al. 2011. J. Immunol. 186:4618. PubMed
  11. Conrad J, et al. 2011. J. Immunol. 186:6871. PubMed
  12. Salisch NC, et al. 2010. J. Immunol. 184:476. (Rhesus reactivity)
  13. Li H and Pauza CD. 2015. Eur. J. Immunol. 45:298. (IHC)
  14. Peterson VM, et al. 2017. Nat. Biotechnol. 35:936. (PG)
  15. Radtke AJ,?et al. 2020.?Proc Natl Acad Sci USA. 117:33455-33465. (SB)?PubMed
  16. Radtke AJ,?et al. 2022.?Nat Protoc. 17:378-401. (SB)?PubMed
Product Citations
  1. Cao B, et al. 2022. Nat Commun. 13:6203. PubMed
  2. Montes de Oca M, et al. 2016. Cell Rep. 17:399-412. PubMed
  3. Zhang Y, et al. 2020. Oncol Lett. 1.053472222. PubMed
  4. Wang Z, et al. 2018. Nat Commun. 9:824. PubMed
  5. Cheng L, et al. 2021. Cancer Immunol Immunother. Online ahead of print. PubMed
  6. Wang S, et al. 2021. Exp Ther Med. 21:37. PubMed
  7. Panwar B, et al. 2021. Genome Res. 31:659. PubMed
  8. Porsche CE, et al. 2021. JCI Insight. 6:. PubMed
  9. Jia X, et al. 2021. Clin Transl Immunology. 10:e1336. PubMed
  10. Daugan MV, et al. 2021. Cancer Immunol Res. 9:891. PubMed
  11. Yamaguchi A, et al. 2021. J Thorac Dis. 13:5430. PubMed
  12. Kraig E, et al. 2018. Exp Gerontol. 105:53. PubMed
  13. Liao JB, et al. 2021. J Immunother Cancer. 9:. PubMed
  14. Miles B, et al. 2015. Nat Commun. 6: 8608. PubMed
  15. Chan JA, et al. 2020. Cell Rep Med. 1:100157. PubMed
  16. Todorova D, et al. 2020. EBioMedicine. 62:103120. PubMed
  17. Wei JL, et al. 2021. J Immunother Cancer. 9: . PubMed
  18. Huang Y, et al. 2020. FASEB J. 34:1768. PubMed
  19. Rodda LB, et al. 2020. Cell. 184(1):169-183.e17. PubMed
  20. Zhang J, et al. 2022. Nature. 609:369. PubMed
  21. Cai J, et al. 2021. eLife. 10:00. PubMed
  22. Martín–Gayo E, et al. 2020. Cell Rep. 30:984. PubMed
  23. Zhu Y, et al. 2019. Cell Stem Cell. 25:542. PubMed
  24. Xu H, et al. 2013. J Leukoc Biol. 93:943. PubMed
  25. Miles B, et al. 2016. PLoS Pathog. 12:e1005924. PubMed
  26. Rasmussen TA, et al. 2022. Cell Rep Med. 3:100766. PubMed
  27. Wang D, et al. 2017. Leukemia. 10.1038/leu.2017.69. PubMed
  28. Zhao Y et al. 2018. Cell reports. 24(2):379-390 . PubMed
  29. Hirama T, et al. 2021. JCI Insight. 6:. PubMed
  30. Paul S, et al. 2021. Sci Transl Med. 13:. PubMed
  31. Ng KW, et al. 2019. eLife. 0.333333333333333. PubMed
  32. Wei J, et al. 2019. J Immunother Cancer. 7:209. PubMed
  33. Liu Y, et al. 2018. Cancer Cell. 33:480. PubMed
  34. Niu C, et al. 2018. Front Immunol. 9:1759. PubMed
  35. Mathewson ND, et al. 2021. Cell. 184(5):1281-1298.e26. PubMed
  36. Frasca D, et al. 2021. Front Immunol. 616650:12. PubMed
  37. Frasca D, et al. 2018. PLoS One. 13:e0197472. PubMed
  38. Renner K, et al. 2020. Cell Reports. 29(1):135-150.e9.. PubMed
  39. Beyer M, et al. 2016. Nat Immunol. 17:593-603. PubMed
  40. Blackburn M, et al. 2015. J Immunol. 195: 3227 - 3236. PubMed
  41. Tian X, et al. 2015. J Immunol. 194:3873. PubMed
  42. Schulthei? C, et al. 2020. Immunity. 53(2):442-455.e4.. PubMed
  43. Zou F, et al. 2019. Nat Commun. 10:4109. PubMed
  44. Lecciso M, et al. 2017. Front Immunol. . 10.3389/fimmu.2017.01918. PubMed
  45. Tan EE, et al. 2020. J Clin Invest. 130:5817. PubMed
  46. Chew G, et al. 2016. PLoS Pathog. 12: 1005349. PubMed
  47. Javed A, et al. 2015. PLoS One. 10: 0142086. PubMed
RRID
AB_940473 (BioLegend Cat. No. 329907) AB_940475 (BioLegend Cat. No. 329908)

Antigen Details

Structure
Immunoglobulin superfamily
Distribution

Transiently expressed on CD4- CD8- thymocytes; upregulated in thymocytes and splenic T and B lymphocytes; expressed on activated myeloid cells

Ligand/Receptor
B7-H1 (also known as PD-L1) and B7-DC (PD-L2)
Cell Type
B cells, Lymphocytes, T cells, Thymocytes, Tregs
Biology Area
Cancer Biomarkers, Immunology, Inhibitory Molecules
Molecular Family
CD Molecules, Immune Checkpoint Receptors
Gene ID
5133 View all products for this Gene ID
UniProt
View information about CD279 on UniProt.org

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