Purified anti-Gelsolin Antibody
- 产品名称：
- Purified anti-Gelsolin Antibody
- 产品类别：
- 抗体
- 产品编号：
- 866501
- 产品应用：
- 866501
- Verified Reactivity
- Human, Drosophila
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant full-length gelsolin protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
IHC-P, ICC - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 ?g per ml. For formalin-fixed paraffin-embedded immunohistochemical staining, a concentration range of 1.0 - 10 ?g/ml is suggested.?For immunocytochemistry, a concentration range of 1.0?- 5.0?μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2810787 (BioLegend Cat. No. 866501) AB_2810788 (BioLegend Cat. No. 866502)
- Structure
- Human gelsolin is a 782 amino acid protein with a molecular mass of 86 kD.
- Distribution
-
Tissue distribution: Central nervous system, phagocytic cells, platelets, fibroblasts, non-muscle cells, smooth and skeletal muscle cells.
Cellular distribution: Cytoskeleton and extracellular
- Function
- Gelsolin is a calcium-binding, actin-modulating protein. It can promote the assembly of actin monomers into filaments as well as sever actin filaments.
- Interaction
- Interacts with actin and fibronectin. Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X.
- Cell Type
- Astrocytes, Microglia, Neurons, Oligodendrocytes
- Biology Area
- Cell Biology, Cell Motility/Cytoskeleton/Structure, Cell Structure, Neurodegeneration, Neuroscience
- Molecular Family
- Cytoskeletal Proteins
- Antigen References
-
- Ji L, et al. 2015. J Alzheimers Dis. 44(1):13-25
- Asch HL, et al. 1996. Cancer Res. 56(21):4841-5.
- Sun HQ, et al. 1999. J Biol Chem. 274(47):33179-82.
- Ji L, et al. 2009. J Alzheimers Dis. 18(1):105-11.
- Gene ID
- 2934 View all products for this Gene ID
- UniProt
- View information about Gelsolin on UniProt.org
