Alexa Fluor® 488 anti-human Granzyme A Antibod
- 产品名称：
- Alexa Fluor® 488 anti-human Granzyme A Antibod
- 产品类别：
- 抗体
- 产品编号：
- 507212
- 产品应用：
- 507212
[价格]
| 规格 |
价格 |
库存 |
| 100tests |
￥ 3180 |
1 |
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Purified human Granzyme A
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor? 488 under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
ICFC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
* Alexa Fluor? 488 has a maximum emission of 519 nm when it is excited at 488 nm.
Alexa Fluor? and Pacific Blue? are trademarks of Life Technologies Corporation.
View full statement regarding label licenses - Excitation Laser
- Blue Laser (488 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: immunohistochemical staining3 of formalin-fixed paraffin-embedded tissue sections, and immunoprecipitation2.
- Application References
(PubMed link indicates BioLegend citation) -
- Trimble L, et al. 1998. Blood 91:585.
- Beresford P, et al. 1997. P. Natl. Acad. Sci. USA 94:9285.
- Raqib R, et al. 2002. Infect. Immun. 70:3199.
- Chen H, et al. 2005. J. Immunol. 175:591.
- Product Citations
-
- Zhang Q, et al. 2022. Nucleic Acids Res. Online ahead of print. PubMed
- Buggert M, et al. 2014. PLoS Pathog. 10:1004251. PubMed
- Tang-Huau TL, et al. 2018. Nat Commun. 9:2570. PubMed
- Wu J, et al. 2020. Sci Adv. 6:eaba3458. PubMed
- RRID
- AB_528909 (BioLegend Cat. No. 507212)
- Structure
- Serine protease; disulfide-linked homodimer; 28 kD (Mammalian)
- Ligand/Receptor
- Assisted by perforin
- Bioactivity
- Induction of caspase-independent cell death by apoptosis; release of NM23-H1 for single-strand DNA nicking
- Cell Sources
- Cytotoxic T cells, NK cells
- Cell Targets
- Intracellular targets lamins A, B cells, C, nucleosome assembly protein (NAP) SET cells, HMG2, Ape1/Ref-1, histones; cleaves SET:NM23-H1 complex to release NM23-H1
- Receptors
- Assisted by perforin
- Cell Type
- Tregs
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Neuroscience
- Molecular Family
- Proteases, Enzymes and Regulators
- Antigen References
-
1. Brune J, et al. 1986. Nature 322:268.
2. Fan Z, et al. 2003. Nature Immunol. 4:145.
3. Fan Z, et al. 2003. Cell 112:659.
4. Masson D, et al. 1987. Cell 49:679.
- Gene ID
- 3001 View all products for this Gene ID
- UniProt
- View information about Granzyme A on UniProt.org
