Purified anti-Caspase-11 Antibody
- 产品名称：
- Purified anti-Caspase-11 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 647201
- 产品应用：
- 647201
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- His tagged bacterial fusion protein of p 30 of caspase 11
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): 1 to 2 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
(PubMed link indicates BioLegend citation) -
- Schmidt RL, et al. 2012. PLoS One. 7:e45186. PubMed.
- Product Citations
-
- Khameneh H, et al. 2011. PLoS One. 6:e23025. PubMed
- Schmidt R, Lenz L 2012. PLoS One. 7:e45186. PubMed
- Min L, et al. 2012. J Immunol. 188:1789. PubMed
- Evavold CL, et al. 2021. Cell. 184(17):4495-4511.e19. PubMed
- RRID
- AB_1937283 (BioLegend Cat. No. 647201) AB_1937281 (BioLegend Cat. No. 647202)
- Structure
- This murine caspase 11 has pro-enzymes a 38 and 43 kD. The activated form consists of p30 and p10.
- Distribution
- Not constitutively expressed in most cell types, but can be induced by different pro-inflmmatory stimuli including LPS.
- Function
- Essential for the activation of caspase-1, thus involved in the maturation of IL-1beta and IL-18. Both are important mediators of inflammation.
- Interaction
- Caspase-1
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Neuroscience
- Antigen References
-
1. Lee J et al. 2001. J. Biol. Chem. 276:32956
2. Schauvliege R et al. 2002. J. Biol. Chem. 277:41624
3. Wang S et al. 1998. Cell 92:501
- Gene ID
- 201161 View all products for this Gene ID
- UniProt
- View information about Caspase-11 on UniProt.org
