Purified anti-human CD30 Antibody
- 产品名称：
- Purified anti-human CD30 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 333902
- 产品应用：
- 333902
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human CD30 boosted with THP-1 cell line
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported application: in combination with IL-2 and PMA to induce T cell clone proliferation.
- Application References
(PubMed link indicates BioLegend citation) -
- Leca G, et al. 1994. Cell. Immunol. 156:230.
- Product Citations
-
- Simonson PD, et al. 2022. Commun Biol. 5:627. PubMed
- RRID
- AB_1134022 (BioLegend Cat. No. 333902)
- Structure
- Type I transmembrane receptor and member of the TNF receptor superfamily that contains 4 TNF receptor domains; predicted molecular weight approximately 64 kD
- Distribution
-
Highly expressed on Hodgkins and Reed-Sternberg cells and activated, but not resting, T cells and B cells.
- Function
- Signaling through CD30 is thought to limit the proliferative potential of autoreactive CD8 effector T cells and protect against autoimmunity.
- Interaction
- TRAF1, TRAF2, TRAF3, TRAF5, NPM-ALK, TRAF-interacting protein, CD30 ligand (CD153)
- Ligand/Receptor
- CD30 Ligand (CD153)
- Cell Type
- B cells, Embryonic Stem Cells, Tregs
- Biology Area
- Immunology, Stem Cells
- Molecular Family
- CD Molecules
- Antigen References
-
1. Durkop H, et al. 1992. Cell 68:421.
2. Aizawa S, et al. 1997. J. Biol. Chem. 272:2042.
3. Stein H, et al. 1982. Int. J. Cancer 30:445.
- Gene ID
- 943 View all products for this Gene ID
- UniProt
- View information about CD30 on UniProt.org
