Purified anti-SOX-10 Antibody
- 产品名称：
- Purified anti-SOX-10 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 847201
- 产品应用：
- 847201
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Synthetic peptide corresponding to the N-terminus of human SOX-10.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
IHC-P - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5.0 - 10 μg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This antibody may show weaker reactivity to human tissues.
- Product Citations
-
- Dravis C et al. 2018. Cancer cell. 34(3):466-482 . PubMed
- RRID
- AB_2734617 (BioLegend Cat. No. 847201) AB_2629666 (BioLegend Cat. No. 847202)
- Structure
- SOX-10 is a 466 amino acid protein with a molecular mass of 50 kD.
- Distribution
-
Tissue distribution: primarily expressed in the nuclei of glia in fetal and adult brain, and in the heart, salivary gland and skin.
Cellular distribution: nucleus.
- Function
- SOX-10 likely functions synergistically with the POU domain protein TST-1/OCT6/SCIP to confer function of other transcription factors in developing and mature glia. The protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development.
- Interaction
- DNA, PAX3, NMI.
- Cell Type
- Microglia
- Biology Area
- Cell Biology, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- Endosomal Markers
- Antigen References
-
1. Bondurand N, Sham MH. 2013. Dev. Biol. 382(1):330. PubMed
2. Mollaaghababa R, Pavan WJ. 2003. Oncogene. 22(20):3024. PubMed
- Gene ID
- 6663 View all products for this Gene ID
- UniProt
- View information about SOX-10 on UniProt.org
