Purified anti-human CD172b (SIRPβ) Antibody
- 产品名称：
- Purified anti-human CD172b (SIRPβ) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 323902
- 产品应用：
- 323902
- Verified Reactivity
- Human
- Reported Reactivity
- Baboon
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- NIH-3T3 cells transfected with SIRPbeta
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
(PubMed link indicates BioLegend citation) -
- Seiffert M, et al. 2001. Blood 97:2741.
- Product Citations
-
- Dutertre CA, et al. 2020. Immunity. 51(3):573-589.e8.. PubMed
- RRID
- AB_2301799 (BioLegend Cat. No. 323902)
- Structure
- Member of the signal regulatory protein family and immunoglobulin superfamily. Single pass transmembrane receptor with immunoglobulin-like domains; lacks cytoplasmic SHP-2 binding domain. Disulfide-linked homodimer, predicted MW ~43 kD.
- Distribution
-
Myeloid cells, monocytes, dendritic cells
- Function
- Negative regulation of tyrosine-kinase coupled signaling processes. Regulates neutrophil transepithelial migration
- Interaction
- DAP12 and Syk (through TYROBP)
- Cell Type
- Dendritic cells, Monocytes
- Biology Area
- Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
1. Kharitonenkov A, et al. 1997. Nature 386:181.
2. Tomasello E, et al. 2000. Eur. J. Immunol. 30:2147.
- Gene ID
- 10326 View all products for this Gene ID
- UniProt
- View information about CD172beta on UniProt.org
