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PE/Cyanine7 anti-human IFN-γ Antibody
产品名称：
PE/Cyanine7 anti-human IFN-γ Antibody
产品类别：
抗体
产品编号：
506517
产品应用：
506517
[价格]
规格 价格 库存
25tests ￥ 1680 1

产品详情

Product Details

Verified Reactivity
Human
Reported Reactivity
Chimpanzee, Baboon, Cynomolgus, Rhesus, African Green, Pigtailed Macaque, Sooty Mangabey
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
E. coli-expressed recombinant human IFN-γ
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE/Cyanine7 under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

ICFC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Flow Cytometry2: The fluorochrome-labeled B27 antibody is useful for intracellular immunofluorescent staining and flow cytometric analysis to identify IFN-? -producing cells within mixed cell populations. For intracellular cytokine staining protocol, please visit www.biolegend.com and click on the support section.
Neutralization1,3,6,7: The Ultra-LEAF? Purified antibody (Endotoxin <0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for neutralization of human IFN-? bioactivity (Cat. No. 506531).

Additional Product Notes

BioLegend is in the process of converting the name PE/Cy7 to PE/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our PE/Cyanine7 products. Please contact Technical Service if you have any questions.

Application References

(PubMed link indicates BioLegend citation)
  1. Favre C, et al. 1989. Molec. Immunol. 26:17. (Neut)
  2. Kaur A, et al. 2002. J Virol. 76:3646.
  3. Abrams J, et al. 1992. Immunol. Rev. 127:5. (Neut)
  4. Andersson U, et al. 1999. Detection and quantification of gene expression. New York:Springer-Verlag.
  5. Rout N, et al. 2010. PLoS One 5:e9787. (FC)
  6. Acosta-Rodriguez EV, et al. 2007. Nat. Immunol. 9:942-9. (Neut)
  7. Gangur V, et al. 1998. FASEB J. 12:705-13. (Neut)
Product Citations
  1. Zhang H, et al. 2021. Front Immunol. 12:644520. PubMed
  2. Barros-Martins J, et al. 2021. Nat Med. 27:1525. PubMed
  3. Chen M, et al. 2021. Cancers (Basel). 13:. PubMed
  4. Cai D, et al. 2021. Front Mol Biosci. 8:686803. PubMed
  5. Boyle M, et al. 2015. J Infect Dis. 212: 416-425. PubMed
  6. Naidoo KK, et al. 2020. PLoS One. 15:e0242448. PubMed
  7. Zhu Y, et al. 2019. Cell Stem Cell. 25:542. PubMed
  8. Li YR, et al. 2021. Cell Rep Med. 2:100449. PubMed
  9. Collins DR, et al. 2021. Immunity. 54:2372. PubMed
  10. Marí?n N, et al. 2012. Clin Vaccine Immunol. 19:1667. PubMed
  11. Behrens GMN, et al. 2022. Nat Commun. 13:4872. PubMed
  12. Csomós K, et al. 2022. Nat Immunol. 23:1256. PubMed
  13. Luetke-Eversloh M, et al. 2014. PLoS Pathog. 10:1004441. PubMed
  14. Lichnog C, et al. 2019. Front Pharmacol. 10:39. PubMed
  15. Wang L, et al. 2018. Oncol Lett. 15:8635. PubMed
  16. Bennstein SB, et al. 2020. eLife. 9:e55232.. PubMed
RRID
AB_2123322 (BioLegend Cat. No. 506517) AB_2123321 (BioLegend Cat. No. 506518)

Antigen Details

Structure
Cytokine; dimer; 20-25 kD (Mammalian)
Bioactivity
Antiviral/antiparasitic activities; inhibits proliferation; enhances MHC class I and II expression on APC
Cell Sources
CD8+ and CD4+ T cells, NK cells
Cell Targets
T cells, B cells, macrophages, NK cells, endothelial cells, fibroblasts
Receptors
IFN-γRα (CDw119) dimerized with IFN-γRβ (AF-1)
Cell Type
Tregs
Biology Area
Cell Biology, Immunology, Neuroinflammation, Neuroscience
Molecular Family
Cytokines/Chemokines
Antigen References

1. Fitzgerald K, et al. Eds. 2001. The Cytokine FactsBook. Academic Press San Diego.
2. De Maeyer E, et al. 1992. Curr. Opin. Immunol. 4:321.
3. Farrar M, et al. 1993. Annu. Rev. Immunol. 11:571.
4. Gray P, et al. 1987. Lymphokines 13:151.

Regulation
Upregulated by IL-2, FGF-basic, EGF; downregulated by vitamin D3 or DMN; labile at pH2
Gene ID
3458 View all products for this Gene ID
UniProt
View information about IFN-gamma on UniProt.org

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