Purified anti-MAG Antibody
- 产品名称：
- Purified anti-MAG Antibody
- 产品类别：
- 抗体
- 产品编号：
- 851701
- 产品应用：
- 851701
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Purified MAG protein isolated from human central nervous system.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB -?Quality tested
IHC-P -?Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 5.0 ?g per ml.?For immunohistochemistry on formalin-fixed paraffin-embedded tissue, a concentration range of 5.0 - 10 ?g/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
(PubMed link indicates BioLegend citation) -
- Dobersen MJ,?et al. 1985.?Neurochem Research. 4: 499 (WB and IHC)
- Cao Z,?et al. 2007.?J Neurosci. 34: 9146?(WB)
- RRID
- AB_2749879 (BioLegend Cat. No. 851701) AB_2749880 (BioLegend Cat. No. 851702)
- Structure
- MAG is a 626 amino acid protein with a molecular mass of 70 kD.
- Distribution
-
Tissue distribution: Central and peripheral nervous system, in periaxonal myelin and at Schmidt-Lanterman incisures.
Cellular distribution: Plasma membrane
- Function
- MAG is involved in the process of axon myelination and maintenance of myelin sheath along axons. MAG also functions as a receptor that promotes differentiation, maintenance and survival of oligodendrocytes. Aberrant immunoreactivity to MAG has been suggested to play a role in the pathogenesis of multiple sclerosis.
- Interaction
- MAG binds to neuronal sialic acid-containing gangliosides and to glycoproteins RTN4R and RTN4RL2.
- Biology Area
- Cell Biology, Neuroinflammation, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- Siglec Molecules
- Antigen References
-
- Dobersen MJ,?et al. 1985.?Neurochem Research. 4: 499
- McKerracher L and Rosen KM. 2015.?Front Mol Neurosci. 8: 51
- Vallat JM,?et al. 2016.?Expert Rev Neurother. 9: 1111
- Gene ID
- 4099 View all products for this Gene ID
- UniProt
- View information about MAG on UniProt.org
