Purified anti-human DcR3 Antibody
- 产品名称：
- Purified anti-human DcR3 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 333202
- 产品应用：
- 333202
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human DcR3 Fc protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
IP, IHC?- Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, suggested working dilution(s): Use 5-20 ?g antibody per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications (for the relevant formats) include: Western blotting1, immunoprecipitation2, and immunohistochemistry2.
- Application References
(PubMed link indicates BioLegend citation) -
- Hsu TL, et al. 2005. J. Immunol. 175:5135. (WB)
- Personal communication (IP IHC ELISA Detection)
- Tai SK, et al. 2012. J. Immunol. 188:2464. PubMed.
- Product Citations
-
- Yang CY, et al. 2019. Head Neck. 41:1260. PubMed
- Tai S, et al. 2012. J Immunol. 188:2464. PubMed
- Weng S, et al. 2015. Sci Rep. 5: 12769. PubMed
- RRID
- AB_2207467 (BioLegend Cat. No. 333202)
- Structure
- Soluble member of the TNF superfamily (6B), contains four TNF-receptor like domains, approximate molecular weight 35 kD.
- Distribution
-
Secreted protein, also found in cytoplasm and endoplasmic reticulum. Expressed by monocytes and myeloid-derived dendritic cells following exposure to bacterial antigens. Overexpressed in tumors including lung and colon cancers, gliomas and pancreatic canc
- Function
- Competes with ligand binding to surface receptors including FasL binding to Fas, LIGHT binding to HVEM and LT-?R, and TNF like molecule 1 (TL1A) with death receptor 3 (DR3). Competition inhibits cell-surface receptor signaling.
- Interaction
- Binds FasL, LIGHT, and TL1A
- Cell Type
- Monocytes, Dendritic cells
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology
- Molecular Family
- Cytokine/Chemokine Receptors
- Antigen References
-
1. Pitti RM, et al. 1998. Nature 396:699.
2. Bai C, et al. 2000. Proc. Natl. Acad. Sci. USA 97:1230.
3. Yu KY, et al. 1999. J. Biol. Chem. 274:13733.
4. Migone TS, et al. 2002. Immunity 16:479.
- Gene ID
- 8771 View all products for this Gene ID
- UniProt
- View information about DcR3 on UniProt.org
