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Purified anti-human CLEC1B (CLEC2) Antibody
产品名称:
Purified anti-human CLEC1B (CLEC2) Antibody
产品类别:
抗体
产品编号:
372002
产品应用:
372002
[价格]
规格 价格 库存
100µg ¥ 3876 1

产品详情

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Extracellular region of CLEC1B (amino acids 68-229).
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
IP, Block - Reported in the literature, not verified in house

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation; inhibition of podoplanin and rhodocytin-mediated platelet activation.

Application References

(PubMed link indicates BioLegend citation)
  1. Gitz E, et al. 2014. Blood 124:2262.
RRID
AB_2632624 (BioLegend Cat. No. 372002)

Antigen Details

Structure
Type II transmembrane protein, 32 kD, homodimer, 1 hemITAM motif.
Distribution
Platelets, megakaryocytes; low expression on myeloid cells.
Function
Mediates platelet activation and aggregation; facilitates capture of HIV by platelets.
Interaction
Syk, PLC-g.
Ligand/Receptor
Rhodocytin, podoplanin.
Cell Type
Platelets, Megakaryocytes, Dendritic cells
Biology Area
Immunology
Antigen References

1. Manne BK, et al. 2015. J. Biol. Chem. 290:11557.
2. Hughes CE, et al. 2013. J. Biol. Chem. 288:5127.
3. Pargui?a AF, et al. 2012. Blood 120:e117-26.
4. Osada M, et al. 2012. J. Biol. Chem. 287:22241.

Gene ID
51266 View all products for this Gene ID
UniProt
View information about CLEC1B on UniProt.org

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