Purified anti-human CLEC1B (CLEC2) Antibody
- 产品名称:
- Purified anti-human CLEC1B (CLEC2) Antibody
- 产品类别:
- 抗体
- 产品编号:
- 372002
- 产品应用:
- 372002
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Extracellular region of CLEC1B (amino acids 68-229).
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
IP, Block - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications (for the relevant formats) include: immunoprecipitation; inhibition of podoplanin and rhodocytin-mediated platelet activation.
- Application References
(PubMed link indicates BioLegend citation) -
- Gitz E, et al. 2014. Blood 124:2262.
- RRID
- AB_2632624 (BioLegend Cat. No. 372002)
- Structure
- Type II transmembrane protein, 32 kD, homodimer, 1 hemITAM motif.
- Distribution
- Platelets, megakaryocytes; low expression on myeloid cells.
- Function
- Mediates platelet activation and aggregation; facilitates capture of HIV by platelets.
- Interaction
- Syk, PLC-g.
- Ligand/Receptor
- Rhodocytin, podoplanin.
- Cell Type
- Platelets, Megakaryocytes, Dendritic cells
- Biology Area
- Immunology
- Antigen References
-
1. Manne BK, et al. 2015. J. Biol. Chem. 290:11557.
2. Hughes CE, et al. 2013. J. Biol. Chem. 288:5127.
3. Pargui?a AF, et al. 2012. Blood 120:e117-26.
4. Osada M, et al. 2012. J. Biol. Chem. 287:22241.
- Gene ID
- 51266 View all products for this Gene ID
- UniProt
- View information about CLEC1B on UniProt.org