Alexa Fluor® 488 anti-human EGFR Antibody
- 产品名称：
- Alexa Fluor® 488 anti-human EGFR Antibody
- 产品类别：
- 抗体
- 产品编号：
- 352908
- 产品应用：
- 352908
[价格]
| 规格 |
价格 |
库存 |
| 100tests |
￥ 4164 |
1 |
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Non-small cell lung cancer (NSCLC) cell line NCI-H322
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor? 488 under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
ICC?- Verified
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?L?per million cells in 100 ?L?staining volume or 5 ?L?per 100 ?L?of whole blood.
* Alexa Fluor? 488 has a maximum emission of 519 nm when it is excited at 488 nm.
Alexa Fluor? and Pacific Blue? are trademarks of Life Technologies Corporation.
View full statement regarding label licenses - Excitation Laser
- Blue Laser (488 nm)
- Application References
(PubMed link indicates BioLegend citation) -
- Yamaguchi M, et al. 2009. The 15th Annual Meeting Japan Society of Gene Therapy. p1056. Abstract 92.
- Product Citations
-
- Arshad N, et al. 2018. J Biol Chem. 293:9555. PubMed
- Kitamura Y, et al. 2021. Sci Adv. 7: . PubMed
- Pham TC, et al. 2021. J Extracell Vesicles. e12057:10. PubMed
- Jayasinghe MK, et al. 2022. Theranostics. 12:3288. PubMed
- Mahameed M, et al. 2020. Nat Commun. 11:1304. PubMed
- Subham S, et al. 2022. Breast Cancer Res Treat. Online ahead of print. PubMed
- Marrocco I, et al. 2021. EMBO Mol Med. 13:e13144. PubMed
- Mahameed M, et al. 2019. Cell Death Dis. 10:300. PubMed
- Salvany‐Celades M et al. 2019. Cell Rep. 27(9):2537-2547 . PubMed
- Staudte S, et al. 2022. Cancers (Basel). 14:. PubMed
- Xuan Z, et al. 2020. Am J Cancer Res. 0.458333333. PubMed
- Liu H, et al. 2020. Cancer Discov. 1.268055556. PubMed
- Kahn S, et al. 2016. EMBO Mol Med. 8: 511 - 526. PubMed
- Leonard B, et al. 2018. Cancer Res. 78:4331. PubMed
- RRID
- AB_11124324 (BioLegend Cat. No. 352907) AB_11126165 (BioLegend Cat. No. 352908)
- Structure
- Member of the protein kinase superfamily; transmembrane glycoprotein; ligand binding induces dimerization and autophosphorylation
- Distribution
-
Epithelial cells and endothelial cells; frequently found in epithelial carcinomas
- Function
- Controls cell growth and differentiation
- Interaction
- MAPK, Akt, JNK
- Ligand/Receptor
- Members of the epidermal growth factor (EGF) family such as EGF, TGF-α, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor
- Cell Type
- Endothelial cells, Epithelial cells
- Biology Area
- Cell Biology, Cell Cycle/DNA Replication, Immunology, Innate Immunity, Neuroscience, Synaptic Biology
- Molecular Family
- CD Molecules, Growth Factors
- Antigen References
-
1. da Cunha Santos G, et al. 2011. Annu. Rev. Pathol. 6:49.
2. Gusterson BA and Hunter KD. 2009. Lancet Oncol. 10:522.
3. Mano M and Humblet Y. 2008. Nat. Clin. Pract. Oncol. 5:415.
4. Pao W and Chmielecki J. 2010. Nat. Rev. Cancer 10:760.
- Gene ID
- 1956 View all products for this Gene ID
- UniProt
- View information about EGFR on UniProt.org
