APC anti-human IRF3 Antibody
- 产品名称：
- APC anti-human IRF3 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 395905
- 产品应用：
- 395905
[价格]
| 规格 |
价格 |
库存 |
| 25tests |
￥ 1788 |
1 |
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human IRF-3 protein (entire protein)
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
ICFC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?L per million cells in 100 ?L staining volume or 5 ?L per 100 ?L of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Red Laser (633 nm)
- Application References
(PubMed link indicates BioLegend citation) -
- Rustagi A, et al. 2012. Methods. 59(2):225-32
- RRID
- AB_2888751 (BioLegend Cat. No. 395905) AB_2888751 (BioLegend Cat. No. 395906)
- Structure
- Human IRF-3 has 427 amino acids with predicted Mw 47.2 kD and observed Mw 52 kD. Contains an IRF tryptophan pentad repeat responsible for DNA binding. Mouse Irf-3 has 419 amino acids with predicted MW 46.9 kD and observed Mw 45 kD.
- Distribution
-
Inactive IRF-3 continuously transits between the cytoplasm and nucleus. Serine/threonine phosphorylation or IRF-3 results in the structural changes which allow IRF-3 activation. The activated IRF3 translocates to the nucleus, where it forms a complex with CREB binding protein and activates the transcription of interferons, interferon stimulated genes, and other antiviral response genes.
- Function
- CREB binding protein, IRF-7, TICAM-1, TICAM-2, non-canonical IKB kinases TBK1 and IKKε.
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Signal Transduction, Transcription Factors
- Molecular Family
- Nuclear Markers
- Antigen References
-
- Pattwell SS, et al. 2017. Trends Mol Med. (9):773-776
- Zhang ZX, et al. 2017. Leuk Lymphoma. 58(3): 646-654
- Zhao B, et al. 2016. Proc Natl Acad Sci USA. 113(24)E3403-12
- Gene ID
- 3661 View all products for this Gene ID
- UniProt
- View information about IRF3 on UniProt.org
