APC anti-mouse CD140a Antibody
- 产品名称：
- APC anti-mouse CD140a Antibody
- 产品类别：
- 抗体
- 产品编号：
- 135907
- 产品应用：
- 135907
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Mouse PDGFR-α-hIgG1 recombinant fusion protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 ?g per 106 cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Red Laser (633 nm)
- Application Notes
Additional reported (for relevant formats) applications include: Western Blot, blocking function2, and immunohistochemical staining of paraffin and frozen sections. The LEAF? purified antibody is recommended for functional assays.
- Application References
(PubMed link indicates BioLegend citation) -
- Takakura N, et al. 1996. J. Invest. Dermatol. 107:770.
- Liao C, et al. 2010. J. Clin. Invest. 120:242. (Block)
- Chen H, et al. 2015. ASN Neuro 8:7. PubMed.
- Miyawaki T, et al. 2004. J Neurosci. 24(37): 8124-34. (IHC-F)
- Product Citations
-
- Wei Y, et al. 2021. Elife. 10: . PubMed
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- Chen YT, et al. 2021. Nat Commun. 12:6845. PubMed
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- Kinsella S, et al. 2021. Cell Rep. 37:109789. PubMed
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- Taguchi A, et al. 2017. Cell Stem Cell. 21:730. PubMed
- Srivastava S, et al. 2019. Cancer Cell. 35:489. PubMed
- Hulsmans M et al. 2017. Cell. 169(3):510-522 . PubMed
- Shook BA, et al. 2020. Cell Stem Cell. 26(6):880-895. PubMed
- Rebekka K Schneider et al. 2017. Cell stem cell. 20(6):785-800 . PubMed
- Hepler C et al. 2018. eLife. 7 pii: e39636. PubMed
- Hiebert P et al. 2018. Developmental cell. 46(2):145-161 . PubMed
- Zhao T et al. 2018. Cell stem cell. 23(1):31-45 . PubMed
- Murakami Y, et al. 2019. Sci Rep. 1.188888889. PubMed
- Shi X, et al. 2022. Clin Transl Med. 12:e711. PubMed
- Oguri Y, et al. 2020. Cell. 182(3):563-577.e20. PubMed
- Jing Y, et al. 2020. Cancer Gene Ther. 27:910. PubMed
- Hogarth MW, et al. 2019. Nat Commun. 10:2430. PubMed
- Avraham S, et al. 2019. Oncogene. 38:3812. PubMed
- Wang QA et al. 2018. Cell metabolism. 28(2):282-288 . PubMed
- Hu Y, et al. 2021. EMBO Rep. 22:e52481. PubMed
- Nowlan B, et al. 2019. Haematologica. 105:71. PubMed
- Dahlgren MW et al. 2019. Immunity. 50(3):707-722 . PubMed
- Moiseenko A, et al. 2020. Cell Rep. 33:108549. PubMed
- Lu Z, et al. 2021. J Clin Invest. 131:. PubMed
- Wang W, et al. 2014. Proc Natl Acad Sci U S A. 111:14466. PubMed
- Kurowska-Stolarska M, et al. 2016. J Allergy Clin Immunol. S0091-6749(16)31132-0. PubMed
- Grainger N, et al. 2020. J Physiol. 598:3283. PubMed
- Cangkrama M, et al. 2020. EMBO Mol Med. 12:e11466. PubMed
- Mohrin M, et al. 2021. Aging Cell. 20:e13313. PubMed
- Singhal P, et al. 2016. Proc Natl Acad Sci U S A. 113: 122 - 127. PubMed
- Chandrakanthan V, et al. 2016. Proc Natl Acad Sci U S A. 113: 2306-2315. PubMed
- Kastenschmidt JM, et al. 2021. Cell Rep. 35:108997. PubMed
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- RRID
- AB_2043969 (BioLegend Cat. No. 135907) AB_2043970 (BioLegend Cat. No. 135908)
- Structure
- Alpha chain of the platelet-derived growth factor receptor, a receptor tyrosine kinase that forms homo- or hetero-dimers on the surface after ligand binding.
- Distribution
-
Expressed on embryonic tissues and mesenchymal-derived cells of adult mouse.
- Function
- Play a role in wound healing and act as a chemoattractant for fibroblasts, smooth muscle cells, glial cells, monocytes and neutrophils.
- Ligand/Receptor
- PDGFs
- Cell Type
- Embryonic Stem Cells, Mesenchymal cells, Mesenchymal Stem Cells
- Biology Area
- Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers, Stem Cells
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
-
1. Mukouyama YS, et al. 2006. Proc Natl Acad Sci USA. 103(5):1551
2. Miyawaki T, et al. 2004. J Neurosci. 24(37):8124
3. Takakura N, et al. 1997. J Histochem Cytochem. 45(6):883
- Gene ID
- 18595 View all products for this Gene ID
- UniProt
- View information about CD140a on UniProt.org
