Purified anti-Adenomatous polyposis coli (APC) Ant
- 产品名称：
- Purified anti-Adenomatous polyposis coli (APC) Ant
- 产品类别：
- 抗体
- 产品编号：
- 850801
- 产品应用：
- 850801
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- N-terminal APC-MBP fusion protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB -?Quality tested
ICC?-?Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 ?g per mL. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications (for the relevant formats) include: immunofluorescence microscopy1.
- Application References
(PubMed link indicates BioLegend citation) -
- Boehlke C, et al. 2013. PLoS One. 8(5):e62165. (IF)
- Hadjihannas MV, et al. 2012. EMBO Rep. 13(4):347-54. (WB)
- Tanneberger K, et al. 2011. J. Biol. Chem. 286(22):19204-14. (WB)
- RRID
- AB_2716017 (BioLegend Cat. No. 850801) AB_2716018 (BioLegend Cat. No. 850802)
- Structure
- APC is a 2843 amino acid protein with a molecular weight of 311 kD.
- Distribution
-
Tissue distribution: expressed in wide variety of normal tissues.
Cellular distribution: cellular junctions, cytoplasm and membranous expression.
- Function
- APC is a tumor suppressor involved in Wnt signaling. It is also involved in additional processes including cell migration and adhesion, transcriptional activation and apoptosis.
- Biology Area
- Cell Biology, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- Tumor Suppressors
- Antigen References
-
1.?Barth AI,?et al.?2008.?Semin. Cell. Dev. Biol.?19(3):245-51.
- Gene ID
- 324 View all products for this Gene ID
- UniProt
- View information about Adenomatous polyposis coli on UniProt.org
