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PE anti-human CD73 (Ecto-5'-nucleotidase) Ant
产品名称:
PE anti-human CD73 (Ecto-5'-nucleotidase) Ant
产品类别:
抗体
产品编号:
344003
产品应用:
344003
[价格]
规格 价格 库存
25tests ¥ 1548 1

产品详情

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Baboon
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications (for the relevant formats) include:immunofluorescence3.

Clone AD2 has been noted to induce clustering and internalization of CD73 in vivo and inhibit metastasis in a murine breast cancer xenograft model4.

Application References

(PubMed link indicates BioLegend citation)
  1. Nakamura T, et al. 1993. J. Immunol. 151:6933.
  2. Liao J, et al. 2011. J Endod. 37:1217. PubMed
  3. Touboul C, et al. 2013. J. Transl. Med. 11:28. (IF)
  4. Terp MG, et al. 2013. J Immunol. 191: 4165-73 (Block)
Product Citations
  1. Sonoda S, et al. 2022. STAR Protoc. 3:101386. PubMed
  2. Liu C, et al. 2022. Regen Ther. 21:192. PubMed
  3. Xin Y, et al. 2021. Stem Cell Res Ther. 49:12. PubMed
  4. Shi L, et al. 2021. Stem Cell Res Ther. 12:147. PubMed
  5. Ryzhov S, et al. 2019. J Am Heart Assoc. 8:e010874. PubMed
  6. Huang X, et al. 2019. Oxid Med Cell Longev. 2019:1305049. PubMed
  7. Gao G, et al. 2022. Am J Cancer Res. 12:1934. PubMed
  8. Sung SE, et al. 2021. Int J Mol Sci. 22:. PubMed
  9. Saze Z, et al. 2013. Blood. 122:9. PubMed
  10. Ali S, et al. 2018. Purinergic Signal. 14:371. PubMed
  11. Sung SE, et al. 2021. Asian Spine J. Online ahead of print.. PubMed
  12. Zhang J, et al. 2022. Int J Mol Sci. 23:. PubMed
  13. Kicova M, et al. 2020. Neoplasma. 67:933. PubMed
  14. Zhang M, et al. 2013. Urology. 81:465. PubMed
  15. Jungwirth N et al. 2018. Journal of molecular neuroscience : MN. 65(1):60-73 . PubMed
  16. Stocco E, et al. 2020. Front Cell Dev Biol. 0.515972222. PubMed
  17. Hasmim M, et al. 2022. Front Immunol. 13:982821. PubMed
  18. Kenswil KJG, et al. 2021. Cell Stem Cell. 28(4):653-670.e11. PubMed
  19. Blázquez-Prunera A, et al. 2017. Stem Cell Res Ther. 10.1186/s13287-017-0552-z. PubMed
  20. Wu L, et al. 2018. Oncol Lett. 15:9507. PubMed
  21. Kolodziej M, et al. 2019. Adipocyte. 0.509722222. PubMed
  22. de Sousa BM, et al. 2021. NPJ Regen Med. 6:80. PubMed
  23. Yoshida R, et al. 2022. Cancer Res. :. PubMed
  24. Peng H, et al. 2020. Ann Transl Med. 0.927777778. PubMed
  25. Zhang Y, et al. 2019. Aging (Albany NY). 11:12641. PubMed
  26. Okamura G, et al. 2020. Int J Mol Sci. 22:00. PubMed
  27. Ross NT, et al. 2020. Nature Chemical Biology. 16(1):50-59.. PubMed
  28. Sun T, et al. 2019. Haematologica. 105:661. PubMed
  29. Yao X, et al. 2022. Bioeng Transl Med. 7:e10250. PubMed
  30. Wang W, et al. 2022. Int J Mol Sci. 23:. PubMed
  31. Labedz-Maslowska A, et al. 2020. Int J Mol Sci. 21:. PubMed
  32. Cantoni C, et al. 2021. Oncoimmunology. 1879530:10. PubMed
  33. He H, et al. 2019. J Cell Mol Med. 23:4139. PubMed
  34. Vaka R, et al. 2022. Stem Cell Res Ther. 13:20. PubMed
  35. Schulthei? C, et al. 2020. Immunity. 53(2):442-455.e4.. PubMed
  36. Dong N, et al. 2022. World J Stem Cells. 14:556. PubMed
  37. Lee EC, et al. 2020. Int J Mol Sci. 21:00. PubMed
  38. Hong Y, et al. 2020. Aging Cell. 19:e13128. PubMed
  39. Chijimatsu R, et al. 2022. Regen Ther. 21:52. PubMed
  40. Bi R, et al. 2020. Osteoarthritis Cartilage. 28:842. PubMed
RRID
AB_1877224 (BioLegend Cat. No. 344003) AB_2298698 (BioLegend Cat. No. 344004)

Antigen Details

Structure
GPI-linked 5'-nucleotidase, 70 kD
Distribution

Subsets of T cells and B cells, mesenchymal stem cells, follicular dendritic cells, endothelial cells, and epithelial cells

Function
Catalyses dephosphorylation of adenosine monophosphate, costimulates T cell activation, mediates adhesion of lymphocytes to follicular dendritic cells and endothelial cells
Cell Type
B cells, Dendritic cells, Endothelial cells, Epithelial cells, Mesenchymal Stem Cells, T cells, Tregs
Biology Area
Costimulatory Molecules, Immunology, Stem Cells
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Zola H, et al. 2007. Leukocyte and stromal Cell Molecules:the CD Markers. A John Wiley & Sons Inc, Publication.
2. Airas L and Jalkanen? S, et al. 1996. Blood 88:1755.
3. Gutensohn W, et al. 1995. Cell Immunol. 161:213.
4. Airas L, et al. 1995. J. Exp. Med. 182:1603.

Gene ID
4907 View all products for this Gene ID
UniProt
View information about CD73 on UniProt.org

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