PE anti-mouse CD93 (AA4.1, early B lineage) Antibo
- 产品名称：
- PE anti-mouse CD93 (AA4.1, early B lineage) Antibo
- 产品类别：
- 抗体
- 产品编号：
- 136503
- 产品应用：
- 136503
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Pre-B lymphoma 70Z/3
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application References
(PubMed link indicates BioLegend citation) -
- McKearn JP, et al. 1984. J. Immunol. 132:332
- Hanihara-Tatsuzaawa F, et al. 2014. J Biol Chem. 289:30925. PubMed
- Product Citations
-
- Meyer SN, et al. 2020. Immunity. 51(3):535-547. PubMed
- Moreau J, et al. 2015. Blood. 126: 1184-1192. PubMed
- Pessoa Rodrigues C, et al. 2021. Sci Adv. 7:. PubMed
- Yousif AS, et al. 2020. Immunity. 54(2):235-246.e5. PubMed
- Lee JL, et al. 2022. Aging Cell. 21:e13692. PubMed
- Sarapulov AV, et al. 2020. Front Immunol. 11:599. PubMed
- Yankova E, et al. 2021. Nature. 593:597. PubMed
- Fredriksson-Lidman K, et al. 2017. PLoS One. 10.1371/journal.pone.0185509. PubMed
- Hanihara-Tatsuzawa F, et al. 2014. J Biol Chem. 389:30925. PubMed
- Sabouri Z, et al. 2016. Nat Commun. 7:13381. PubMed
- Wang J, et al. 2020. Cell. 183(7):1867-1883.e26. PubMed
- Silva N, et al. 2016. J Immunol. 196: 2591 - 2601. PubMed
- RRID
- AB_1967094 (BioLegend Cat. No. 136503) AB_1967125 (BioLegend Cat. No. 136504)
- Structure
- A 130-140 kD C-type lectin like type I transmembrane protein, also known as complement component 1, q subcomponent (C1qR1), C1qRp collectin receptor (C1qRp), or AA4 antigen.
- Distribution
-
Expressed during immature B lymphocytes, hematopoietic progenitors and stem cells in bone marrow, immature dendritic cells, monocytes, macrophages, and endothelial cells.
- Function
- CD93 plays an important role in maintaining of plasma cells in bone marrow niches. It may play a role in uptake of particles by DC and the in vivo clearance of dying cells by macrophages.
- Cell Type
- B cells, Dendritic cells, Endothelial cells, Hematopoietic stem and progenitors, Macrophages, Monocytes
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
- Molecular Family
- CD Molecules
- Antigen References
-
1. Steinberger P, et al. 2002. J. Leukoc. Biol. 71:133
2. Chevrier S, et al. 2009. Proc. Nat. Acad. Sci. U. S. A. 106:3895
3. Norsworthy PJ, et al. 2004. J. Immunol. 172:3406
4. Li YS, et al. 1996. Immunity 5:527
5. Szilvassy SJ, et al. 1993. Blood 81:2310
- Gene ID
- 17064 View all products for this Gene ID
- UniProt
- View information about CD93 on UniProt.org
