Purified anti-mouse CD127 (IL-7Rα) Antibody -上海雅吉生物科技有限公司

规格	价格	库存
500µg	￥ 1632	1

Product Details

Verified Reactivity

Mouse

Antibody Type

Monoclonal

Host Species

Rat

Immunogen

IL-7Ra-IgG1 fusion protein

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography.

Concentration

0.5 mg/mL

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C.

Application

FC - Quality tested
IP, WB, IHC, ICC?- Reported in the literature, not verified in house

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 ?g per million cells in 100 ?L?volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

A7R34 is able to block clone SB/199 binding to IL-7R.

Application References (PubMed link indicates BioLegend citation)

Sudo T, et al. 1993. P. Natl. Acad. Sci. USA 90:9125.
Hashi H, et al. 2001. J. Immunol. 166:3702.
Taylor R, et al. 2007. J. Immunol. 178:5659.
Mazzon C, et al. 2011. Blood. 118:2733. PubMed
Jin J, et al. 2011. J. Immunol. doi:10.4049/jimmunol.1001238. PubMed

Product Citations

Khan KA, et al. 2020. NPJ Breast Cancer. 6:29. PubMed
Arnold IC, et al. 2018. J Exp Med. 215:2055. PubMed
De Vlaeminck Y, et al. 2020. Cancers (Basel). 12:. PubMed
Nguyen N, et al. 2022. iScience. 25:103679. PubMed
Carpenter SM, et al. 2017. PLoS Pathog. 13:e1006704. PubMed
Shen G, et al. 2017. Eur J Immunol. 47:900. PubMed
Qin Q, et al. 2017. Virology. 502:198. PubMed
Morabito KM, et al. 2017. Mucosal Immunol. 0.795138889. PubMed
Zhou D, et al. 2022. Nat Commun. 13:5174. PubMed
Khan KA, et al. 2020. NPJ Breast Cancer. 6:29. PubMed
Hsiao CC, et al. 2021. Cells. 10:. PubMed
Sun Y, et al. 2020. J Immunol. 205:3358. PubMed
Mazzon C, et al. 2011. Blood. 118:2733. PubMed
Verbiest T, et al. 2018. Leukemia. 32:1435. PubMed
Neumann K, et al. 2017. J Immunol. 198(1):128-137. PubMed
Gubin MM, et al. 2018. Cell. 175:1014. PubMed
Parigi SM, et al. 2018. Sci Rep. 0.440277778. PubMed
Karmaus PWF, et al. 2019. Nature. 565:101. PubMed
Kakaradov B, et al. 2017. Nat Immunol. 18:422. PubMed
Inclan-Rico JM, et al. 2020. PLoS Pathog. 16:e1008579. PubMed
Link CWM, et al. 2020. Front Immunol. 11:596772. PubMed
Wagner AK, et al. 2017. Nat Commun. 8:15627. PubMed
Stelekati E, et al. 2018. Cell Rep. 2.445833333. PubMed
Sudan R, et al. 2022. Front Immunol. 13:830961. PubMed
Schnoegl D, et al. 2022. Front Immunol. 13:909270. PubMed
Xu W, et al. 2021. Immunity. 54(3):526-541.e7. PubMed
Maier B, et al. 2020. Nature. 580:257. PubMed
An Y et al. 2018. Cell reports. 25(3):702-714 . PubMed
K?stele V, et al. 2021. Mucosal Immunol. 14:717. PubMed
Sutiwisesak R, et al. 2020. PLoS Pathog. 16:e1009000. PubMed

RRID

AB_1937287 (BioLegend Cat. No. 135002)

Antigen Details

Structure: Type I transmembrane glycoprotein, associate with CD132, 60-90 kD
Distribution: Immature B cells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, bone marrow stromal cells
Function: T cell and immature B cell proliferation and development
Ligand/Receptor: IL-7
Cell Type: B cells, T cells, Thymocytes
Biology Area: Immunology
Molecular Family: CD Molecules, Cytokine/Chemokine Receptors
Antigen References: 1. Sudo T, et al. 1993. P. Natl. Acad. Sci. USA 90:9125.
2. Okuno Y, et al. 2001. P. Natl. Acad. Sci. USA 99:6246.
3. Pillai M, et al. 2004. Leukemia Lymphoma 45:2403.
Gene ID: 16197 View all products for this Gene ID
UniProt: View information about CD127 on UniProt.org

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