PE/Cyanine7 anti-mouse CD127 (IL-7Rα) Antibo
- 产品名称：
- PE/Cyanine7 anti-mouse CD127 (IL-7Rα) Antibo
- 产品类别：
- 抗体
- 产品编号：
- 135013
- 产品应用：
- 135013
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- IL-7Ra-IgG1 fusion protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with PE/Cyanine7 under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
- Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
A7R34 is able to block clone SB/199 binding to IL-7R.
- Additional Product Notes
- BioLegend is in the process of converting the name PE/Cy7 to PE/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our PE/Cyanine7 products. Please contact Technical Service if you have any questions.
- Application References
(PubMed link indicates BioLegend citation) -
- Sudo T, et al. 1993. P. Natl. Acad. Sci. USA 90:9125.
- Hashi H, et al. 2001. J. Immunol. 166:3702.
- Taylor R, et al. 2007. J. Immunol. 178:5659.
- Mazzon C, et al. 2011. Blood. 118:2733. PubMed
- Jin J, et al. 2011. J. Immunol. doi:10.4049/jimmunol.1001238. PubMed
- Product Citations
-
- Hutter K, et al. 2022. Front Immunol. 13:967914. PubMed
- Zheng X, et al. 2019. PLoS Pathog. 15:e1008036. PubMed
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- Pokrovskii M, et al. 2019. Immunity. 51:185. PubMed
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- Yamamoto R et al. 2018. Cell stem cell. 22(4):600-607 . PubMed
- LaFleur MW, et al. 2019. Nat Immunol. 20:1335. PubMed
- Paiva RS, et al. 2021. Eur J Immunol. 51:1968. PubMed
- Zhang B, et al. 2022. J Exp Med. 219:. PubMed
- Paiva RA, et al. 2021. Cell Reports. 35(2):108967. PubMed
- Shimokawa C et al. 2017. Immunity. 46(5):863-874 . PubMed
- Ramos CV, et al. 2020. Cell Reports. 32(3):107910. PubMed
- He X, et al. 2021. Adv Sci (Weinh). 8:e2103023. PubMed
- Hurrell BP, et al. 2019. Cell Rep. 29:4509. PubMed
- Xu H, et al. 2020. Immunity. 51(4):696-708.e9.. PubMed
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- LaFleur MW, et al. 2019. Nat Commun. 10:1668. PubMed
- Galle-Treger L, et al. 2020. J Allergy Clin Immunol. 145:502. PubMed
- Shafiei-Jahani P, et al. 2021. Nat Commun. 12:2526. PubMed
- Galle-Treger L, et al. 2016. Nat Commun. 7:13202. PubMed
- Fang H, et al. 2020. Nat Commun. 4.661805556. PubMed
- Galle-Treger L, et al. 2019. Nat Commun. 10:713. PubMed
- Toshiro Hirai et al. 2019. Immunity. 50(5):1249-1261 . PubMed
- Olguín JE, et al. 2018. J Cancer. 9:239. PubMed
- Lehrke MJ, et al. 2021. Elife. 10:. PubMed
- Dahlgren MW et al. 2019. Immunity. 50(3):707-722 . PubMed
- Omatsu Y, et al. 2022. Nat Commun. 13:2654. PubMed
- Richardson ET, et al. 2015. PLoS One. 10: 1371. PubMed
- Nagashima H et al. 2019. Immunity. 51(4):682-695 . PubMed
- Mah-Som AY, et al. 2021. Cell Reports. 35(9):109209. PubMed
- Amezcua Vesely MC, et al. 2020. Cell. 178(5):1176-1188.e15.. PubMed
- Chao JL, et al. 2021. Cell Rep Med. 2:100399. PubMed
- Satoh–Takayama N, et al. 2020. Immunity. 52(4):635-649. PubMed
- Chetty A, et al. 2021. Cell Host Microbe. 29:579. PubMed
- Zhong C, et al. 2020. Immunity. 52(1):83-95.e4.. PubMed
- Goc J, et al. 2021. Cell. :. PubMed
- Radulovic V, et al. 2020. Cell Reports. 27(10):2826-2836.e5.. PubMed
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- RRID
- AB_1937266 (BioLegend Cat. No. 135013) AB_1937265 (BioLegend Cat. No. 135014)
- Structure
- Type I transmembrane glycoprotein, associate with CD132, 60-90 kD
- Distribution
-
Immature B cells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, bone marrow stromal cells
- Function
- T cell and immature B cell proliferation and development
- Ligand/Receptor
- IL-7
- Cell Type
- B cells, T cells, Thymocytes
- Biology Area
- Immunology
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
-
1. Sudo T, et al. 1993. P. Natl. Acad. Sci. USA 90:9125.
2. Okuno Y, et al. 2001. P. Natl. Acad. Sci. USA 99:6246.
3. Pillai M, et al. 2004. Leukemia Lymphoma 45:2403.
- Gene ID
- 16197 View all products for this Gene ID
- UniProt
- View information about CD127 on UniProt.org
