PE anti-mouse CD127 (IL-7Rα) Antibody
- 产品名称：
- PE anti-mouse CD127 (IL-7Rα) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 135009
- 产品应用：
- 135009
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- IL-7Ra-IgG1 fusion protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
A7R34 is able to block clone SB/199 binding to IL-7R.
- Application References
(PubMed link indicates BioLegend citation) -
- Sudo T, et al. 1993. P. Natl. Acad. Sci. USA 90:9125.
- Hashi H, et al. 2001. J. Immunol. 166:3702.
- Taylor R, et al. 2007. J. Immunol. 178:5659.
- Mazzon C, et al. 2011. Blood. 118:2733. PubMed
- Jin J, et al. 2011. J. Immunol. doi:10.4049/jimmunol.1001238. PubMed
- Product Citations
-
- Petrova T, et al. 2020. Sci Rep. 10:3479. PubMed
- Garo LP, et al. 2021. Nat Commun. 12:2419. PubMed
- Zheng X, et al. 2019. PLoS Pathog. 15:e1008036. PubMed
- Wei H, et al. 2021. Malar J. 20:89. PubMed
- Duan Q, et al. 2021. Front Cell Dev Biol. 9:761193. PubMed
- Wang D, et al. 2018. Immunity. 48:659. PubMed
- Gupta SS, et al. 2019. Cell Rep. 29:1862. PubMed
- Mann M, et al. 2018. Cell Rep. 25:2992. PubMed
- Wu J, et al. 2020. Sci Adv. 6:eaba3458. PubMed
- Parriott G, et al. 2020. Immunology. 160:280. PubMed
- Zhuang Z, et al. 2021. J Exp Med. 218:00:00. PubMed
- Zebley CC, et al. 2021. Cell Rep. 37:109796. PubMed
- Jassinskaja M, et al. 2021. Cell Reports. 34(12):108894. PubMed
- Emg?rd J, et al. 2018. Immunity. 143:419. PubMed
- Zhang B, et al. 2021. Nat Biomed Eng. 5:1288. PubMed
- Flommersfeld S, et al. 2021. Immunity. :. PubMed
- Prosser A, et al. 2021. Cell Reports. 35(7):109141. PubMed
- Kotfis K, et al. 2020. British Journal of Pharmacology. 49(1):66-72. PubMed
- Chen X et al. 2017. Cell stem cell. 21(6):747-760 . PubMed
- Cong J et al. 2018. Cell metabolism. 28(2):243-255 . PubMed
- Pardy RD, et al. 2021. Nat Commun. 12:4051. PubMed
- de Lucía Finkel P, et al. 2021. Sci Rep. 11:12233. PubMed
- La Rose AM, et al. 2021. Mol Metab. 53:101265. PubMed
- Belyaev N, et al. 2010. Nat Immunol. 11:477. PubMed
- White C, et al. 2015. J Immunol. 194:697. PubMed
- Kruta M, et al. 2021. Cell Stem Cell. :. PubMed
- Chen H, et al. 2021. iScience. 24:103387. PubMed
- Pandit M, et al. 2021. Eur J Immunol. 51:1461. PubMed
- Dekhtiarenko I, et al. 2016. PLoS Pathog. 12:e1006072. PubMed
- Chang P, et al. 2012. J Immunol. 189: 701. PubMed
- Wang D, et al. 2022. EMBO Rep. 23:e53691. PubMed
- Baja?a S, et al. 2022. iScience. 25:103732. PubMed
- Chen C, et al. 2020. Cell Rep. 2136:30. PubMed
- Sun Y, et al. 2020. J Immunol. 205:2649. PubMed
- Dhayade S, et al. 2020. Nutrients. 12:. PubMed
- Magee JA, et al. 2021. Stem Cell Reports. 16:20. PubMed
- Gaya M et al. 2018. Cell. 172(3):517-533 . PubMed
- Prosser A, et al. 2021. STAR Protoc. 2:100810. PubMed
- Hidalgo San Jose L, et al. 2020. Cell Rep. 30:69. PubMed
- Lu Y, et al. 2018. Cancer Cell. 33:1048. PubMed
- Spiljar M, et al. 2021. Cell Metab. 33:2231. PubMed
- Heyde A, et al. 2021. Cell. 184(5):1348-1361.e22. PubMed
- RRID
- AB_1937252 (BioLegend Cat. No. 135009) AB_1937251 (BioLegend Cat. No. 135010)
- Structure
- Type I transmembrane glycoprotein, associate with CD132, 60-90 kD
- Distribution
-
Immature B cells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, bone marrow stromal cells
- Function
- T cell and immature B cell proliferation and development
- Ligand/Receptor
- IL-7
- Cell Type
- B cells, T cells, Thymocytes
- Biology Area
- Immunology
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
-
1. Sudo T, et al. 1993. P. Natl. Acad. Sci. USA 90:9125.
2. Okuno Y, et al. 2001. P. Natl. Acad. Sci. USA 99:6246.
3. Pillai M, et al. 2004. Leukemia Lymphoma 45:2403.
- Gene ID
- 16197 View all products for this Gene ID
- UniProt
- View information about CD127 on UniProt.org
