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Brilliant Violet 421™ anti-mouse CD127 (IL-7
产品名称：
Brilliant Violet 421™ anti-mouse CD127 (IL-7
产品类别：
抗体
产品编号：
135023
产品应用：
135023
[价格]
规格 价格 库存
125µL ￥ 2580 1

产品详情

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
IL-7Ra-IgG1 fusion protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
Preparation
The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421? under optimal conditions.
Concentration
?g sizes: 0.2 mg/mL
?L sizes: lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining using the ?g size, the suggested use of this reagent is ≤0.5 ?g per million cells in 100 ?l volume. For immunofluorescent staining using ?l sizes, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Brilliant Violet 421? excites at 405 nm and emits at 421 nm. The standard bandpass filter 450/50 nm is recommended for detection. Brilliant Violet 421? is a trademark of Sirigen Group Ltd.


Learn more about Brilliant Violet?.

This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.
Excitation Laser
Violet Laser (405 nm)
Application Notes

A7R34 is able to block clone SB/199 binding to IL-7R.

Additional Product Notes

View more applications data for this product in our Scientific Poster Library.

Application References

(PubMed link indicates BioLegend citation)
  1. Sudo T, et al. 1993. P. Natl. Acad. Sci. USA 90:9125.
  2. Hashi H, et al. 2001. J. Immunol. 166:3702.
  3. Taylor R, et al. 2007. J. Immunol. 178:5659.
  4. Mazzon C, et al. 2011. Blood. 118:2733. PubMed
  5. Jin J, et al. 2011. J. Immunol. doi:10.4049/jimmunol.1001238. PubMed
Product Citations
  1. Lawson H, et al. 2021. Stem Cell Reports. 16:2784. PubMed
  2. Li B, Schmidt N 2016. PLoS One. 11: 0162427. PubMed
  3. Hirai T, et al. 2020. Immunity. 54(1):84-98.e5. PubMed
  4. Michela Miani et al. 2018. Cell metabolism. 28(4):557-572 . PubMed
  5. Flamar AL, et al. 2020. Immunity. 52(4):606-619.e6.. PubMed
  6. Schloss MJ, et al. 2022. Nat Immunol. 23:605. PubMed
  7. Van Den Eeckhout B, et al. 2020. NPJ Vaccines. 5:64. PubMed
  8. Sasse C, et al. 2022. Pathogens. 11:. PubMed
  9. Delacher M, et al. 2021. Immunity. 54(4):702-720.e17. PubMed
  10. Hiraishi Y, et al. 2018. Sci Rep. 8:18052. PubMed
  11. Shikatani EA et al. 2019. Cell Rep. 27(8):2304-2312 . PubMed
  12. Schmidleithner L et al. 2019. Immunity. 50(5):1232-1248 . PubMed
  13. Zong L, et al. 2021. NPJ Aging Mech Dis. 7:25. PubMed
  14. LaFleur MW, et al. 2019. Nat Immunol. 20:1335. PubMed
  15. Francian A, et al. 2021. J Drug Target. 29:754. PubMed
  16. Lee RD, et al. 2021. Nat Commun. 12:6843. PubMed
  17. Anderson CK et al. 2019. Cell Rep. 27(2):537-548 . PubMed
  18. Dikiy S, et al. 2021. Immunity. 54(5):931-946.e11. PubMed
  19. Chopin M et al. 2018. Immunity. 50(1):77-90 . PubMed
  20. He J, et al. 2020. Cell Reports. 29(9):2718-2730.e6.. PubMed
  21. Ma EH, et al. 2020. Immunity. 51(5):856-870. PubMed
  22. Cassidy BR, et al. 2020. J Neuroinflammation. 17:259. PubMed
  23. Cha SE, et al. 2021. Oncoimmunology. 10:1899469. PubMed
  24. Zenke S, et al. 2020. Immunity. 52(2):313-327. PubMed
  25. Snell LM, et al. 2018. Immunity. 49:678. PubMed
  26. Yue X, et al. 2019. Nat Commun. 10:2011. PubMed
  27. Bergin SM, et al. 2021. Brain Behav Immun. 95:477. PubMed
  28. Zhang Y, et al. 2021. J Immunol Res. 2021:5599439. PubMed
  29. McFarland AP, et al. 2021. Immunity. 54(6):1320-1337.e4. PubMed
  30. Milner JJ, et al. 2020. Immunity. 52(5):808-824.e7. PubMed
  31. Kumar MP, et al. 2018. Cell Rep. 25:1458. PubMed
  32. LaFleur MW, et al. 2019. Nat Commun. 10:1668. PubMed
  33. Sheldon RD, et al. 2021. Nat Protoc. 16:4494. PubMed
  34. Uslu M, et al. 2020. J Cell Physiol. 235:9644. PubMed
  35. Frost JN, et al. 2021. Med (N Y). 2:164. PubMed
  36. Ying Zhang et al. 2017. Cancer cell. 32(3):377-391 . PubMed
  37. Gagnon JD, et al. 2019. Cell Rep. 28:2169. PubMed
  38. Siegemund S, et al. 2015. PLoS One. 10:124661. PubMed
  39. Toshiro Hirai et al. 2019. Immunity. 50(5):1249-1261 . PubMed
  40. Moguche AO et al. 2017. Cell host & microbe. 21(6):695-706 . PubMed
  41. Nenasheva T, et al. 2017. PLoS One. 12(6):e0178983. PubMed
  42. Lu YJ, et al. 2021. Cell Rep. 36:109696. PubMed
  43. Limbach K, et al. 2017. Malar J. 10.1186/s12936-017-1911-z. PubMed
  44. Abdelsamed HA, et al. 2020. Nat Immunol. 1.276388889. PubMed
  45. Fan MY et al. 2018. Cell reports. 25(5):1204-1213 . PubMed
  46. Hackstein CP, et al. 2022. Nat Commun. 13:7472. PubMed
  47. Van Den Eeckhout B, et al. 2020. NPJ Vaccines. 0.252777778. PubMed
  48. Waldman MM, et al. 2022. Front Immunol. 13:856977. PubMed
  49. Huang X, et al. 2021. Immunity. . PubMed
  50. Wang X, et al. 2021. Immunity. 54(6):1123-1136.e8. PubMed
RRID
AB_10897948 (BioLegend Cat. No. 135023) AB_2563103 (BioLegend Cat. No. 135027) AB_11218800 (BioLegend Cat. No. 135024)

Antigen Details

Structure
Type I transmembrane glycoprotein, associate with CD132, 60-90 kD
Distribution

Immature B cells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, bone marrow stromal cells

Function
T cell and immature B cell proliferation and development
Ligand/Receptor
IL-7
Cell Type
B cells, T cells, Thymocytes
Biology Area
Immunology
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References

1. Sudo T, et al. 1993. P. Natl. Acad. Sci. USA 90:9125.
2. Okuno Y, et al. 2001. P. Natl. Acad. Sci. USA 99:6246.
3. Pillai M, et al. 2004. Leukemia Lymphoma 45:2403.

Gene ID
16197 View all products for this Gene ID
UniProt
View information about CD127 on UniProt.org

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