Biotin anti-mouse CD127 (IL-7Rα) Antibody
- 产品名称：
- Biotin anti-mouse CD127 (IL-7Rα) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 135005
- 产品应用：
- 135005
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- IL-7Ra-IgG1 fusion protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
A7R34 is able to block clone SB/199 binding to IL-7R.
- Application References
(PubMed link indicates BioLegend citation) -
- Sudo T, et al. 1993. P. Natl. Acad. Sci. USA 90:9125.
- Hashi H, et al. 2001. J. Immunol. 166:3702.
- Taylor R, et al. 2007. J. Immunol. 178:5659.
- Mazzon C, et al. 2011. Blood. 118:2733. PubMed
- Jin J, et al. 2011. J. Immunol. doi:10.4049/jimmunol.1001238. PubMed
- Product Citations
-
- Florentin J, et al. 2022. Front Immunol. 13:882484. PubMed
- Bouchareychas L, et al. 2021. iScience. 24(8):102847. PubMed
- Fuster JJ, et al. 2020. Cell Rep. 33:108326. PubMed
- Lu SX, et al. 2021. Cell. . PubMed
- Mann M, et al. 2018. Cell Rep. 25:2992. PubMed
- Dave K et al. 2017. eLife. 6 pii: e23382. PubMed
- Liu YY, et al. 2020. Chin Med J (Engl). 133:1688. PubMed
- Kim SP, et al. 2021. Cell Reports. 36(9):109626. PubMed
- Chen X et al. 2017. Cell stem cell. 21(6):747-760 . PubMed
- Knolle MD et al. 2018. Frontiers in immunology. 1.925 . PubMed
- Yankova E, et al. 2021. Nature. 593:597. PubMed
- Murakami K, et al. 2021. Cell Reports. 34(1):108579. PubMed
- Bouchareychas L, et al. 2020. Cell Reports. 32(2):107881. PubMed
- Bagadia P, et al. 2019. Nat Immunol. 20:1174. PubMed
- Vasamsetti SB, et al. 2018. Immunity. 49:93. PubMed
- Michel A, et al. 2013. J Immunol. 90:5534. PubMed
- Shimba A et al. 2018. Immunity. 48(2):286-298 . PubMed
- Yoshida H, et al. 2019. Cell. 176:897. PubMed
- Riedel SS, et al. 2021. Molecular Cell. 81(11):2332-2348.e9. PubMed
- Wang J, et al. 2020. Cell Stem Cell. 27(1):81-97. PubMed
- Li ZG, et al. 2020. Chin Med J (Engl). 1943:133. PubMed
- RRID
- AB_1953262 (BioLegend Cat. No. 135005) AB_2126118 (BioLegend Cat. No. 135006)
- Structure
- Type I transmembrane glycoprotein, associate with CD132, 60-90 kD
- Distribution
-
Immature B cells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, bone marrow stromal cells
- Function
- T cell and immature B cell proliferation and development
- Ligand/Receptor
- IL-7
- Cell Type
- B cells, T cells, Thymocytes
- Biology Area
- Immunology
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
-
1. Sudo T, et al. 1993. P. Natl. Acad. Sci. USA 90:9125.
2. Okuno Y, et al. 2001. P. Natl. Acad. Sci. USA 99:6246.
3. Pillai M, et al. 2004. Leukemia Lymphoma 45:2403.
- Gene ID
- 16197 View all products for this Gene ID
- UniProt
- View information about CD127 on UniProt.org
