APC anti-mouse CD127 (IL-7Rα) Antibody
- 产品名称：
- APC anti-mouse CD127 (IL-7Rα) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 135011
- 产品应用：
- 135011
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- IL-7Ra-IgG1 fusion protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
- Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Red Laser (633 nm)
- Application Notes
A7R34 is able to block clone SB/199 binding to IL-7R.
- Application References
(PubMed link indicates BioLegend citation) -
- Sudo T, et al. 1993. P. Natl. Acad. Sci. USA 90:9125.
- Hashi H, et al. 2001. J. Immunol. 166:3702.
- Taylor R, et al. 2007. J. Immunol. 178:5659.
- Mazzon C, et al. 2011. Blood. 118:2733. PubMed
- Jin J, et al. 2011. J. Immunol. doi:10.4049/jimmunol.1001238. PubMed
- Product Citations
-
- Sharma GP, et al. 2021. PLoS One. 16:e0259042. PubMed
- Paprckova D, et al. 2022. Front Immunol. 13:1009198. PubMed
- Misumi I et al. 2019. Cell Rep. 27(2):514-524 . PubMed
- Mitchell JE, et al. 2021. Cell Reports. 35(2):108966. PubMed
- Kurkewich J, et al. 2016. PLoS One. 11: 0161468. PubMed
- Davidson S, et al. 2020. Cell Reports. 31(7):107628. PubMed
- Ramos CV, et al. 2020. Cell Reports. 32(3):107910. PubMed
- Pfenninger P, et al. 2022. Front Immunol. 13:777113. PubMed
- Zhao H, et al. 2021. Int J Nanomedicine. 16:4913. PubMed
- Nakajima T, et al. 2021. J Exp Med. 218:. PubMed
- Volberding PJ, et al. 2021. Cell Reports. 35(8):109160. PubMed
- Zhang C, et al. 2020. Cell Rep. 32:108206. PubMed
- Zaro BW, et al. 2020. eLife. 9:00. PubMed
- Liu W, et al. 2019. Epigenetics. 1.192361111. PubMed
- Ding P, et al. 2022. Bone Res. 10:42. PubMed
- Galle-Treger L, et al. 2016. Nat Commun. 7:13202. PubMed
- Xu X, et al. 2018. J Dermatol Sci. 91:134. PubMed
- Zeis P, et al. 2020. Immunity. 53:775. PubMed
- Hu Z, et al. 2020. PLoS One. 15:e0228339. PubMed
- Daneshmandi S, et al. 2021. Cell Reports. 34(10):108831. PubMed
- Baja?a S, et al. 2022. iScience. 25:103732. PubMed
- Panagi M, et al. 2020. Theranostics. 10:1910. PubMed
- Fujimoto M, et al. 2022. Nat Commun. 13:5408. PubMed
- Hackstein CP, et al. 2022. Nat Commun. 13:7472. PubMed
- Singhal P, et al. 2016. Proc Natl Acad Sci U S A. 113: 122 - 127. PubMed
- Rossnagl S, et al. 2016. PLoS Biol. 14: 1002562. PubMed
- Ding Z, et al. 2017. Sci Rep. 10.1038/s41598-017-12488-z. PubMed
- RRID
- AB_1937217 (BioLegend Cat. No. 135011) AB_1937216 (BioLegend Cat. No. 135012)
- Structure
- Type I transmembrane glycoprotein, associate with CD132, 60-90 kD
- Distribution
-
Immature B cells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, bone marrow stromal cells
- Function
- T cell and immature B cell proliferation and development
- Ligand/Receptor
- IL-7
- Cell Type
- B cells, T cells, Thymocytes
- Biology Area
- Immunology
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
-
1. Sudo T, et al. 1993. P. Natl. Acad. Sci. USA 90:9125.
2. Okuno Y, et al. 2001. P. Natl. Acad. Sci. USA 99:6246.
3. Pillai M, et al. 2004. Leukemia Lymphoma 45:2403.
- Gene ID
- 16197 View all products for this Gene ID
- UniProt
- View information about CD127 on UniProt.org
