PE anti-mouse CD256 (APRIL) Antibody
- 产品名称：
- PE anti-mouse CD256 (APRIL) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 136703
- 产品应用：
- 136703
- Verified Reactivity
- Mouse, Human
- Antibody Type
- Monoclonal
- Host Species
- Armenian Hamster
- Immunogen
- Fusion protein of murine Maltose binding protein (MBP) and soluble April
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
ICFC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.06 ?g per 106 cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Product Citations
-
- Moreau J, et al. 2015. Blood. 126: 1184-1192. PubMed
- Wang W, et al. 2014. J Immunol. 192:3011. PubMed
- RRID
- AB_2206542 (BioLegend Cat. No. 136703) AB_2206541 (BioLegend Cat. No. 136704)
- Structure
- Transmembranal protein of 26 kD, forms a homotrimer that is cleaved from the cell surface resulting in the soluble form. forms heterotrimers with BLyS
- Distribution
-
T cells, B cells, dendritic cells, monocytes, and macrophages
- Function
- Induces proliferation of T and B cells, promotes IgA class switching and downregulates T-cell dependent antibody responses, regulates the growth of a variety of tumor cells.
- Ligand/Receptor
- TNFRSF13b/TACI, TNFRSF17/BCMA
- Bioactivity
- Proliferation, apoptosis inhibition, IgA class switch.
- Cell Type
- B cells, Dendritic cells, Macrophages, Monocytes, T cells
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Signal Transduction
- Molecular Family
- Cytokines/Chemokines
- Antigen References
-
1. Belnoue E, et al. 2008 Blood 111:2755.
2. Xie P, et al. 2007. Immunity 27:253.
3. Mohr E, et al. 2009. J. Immunol. 182:2113.
4. Tezuka H, et al. 2007. Nature 448:92.
5. Benson MJ, et al. 2008. J. Immunol. 180:3655.
- Gene ID
- 69583 View all products for this Gene ID
- UniProt
- View information about CD256 on UniProt.org
