Purified anti-Parkin Antibody
- 产品名称：
- Purified anti-Parkin Antibody
- 产品类别：
- 抗体
- 产品编号：
- 870501
- 产品应用：
- 870501
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant full-length human Parkin protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
IHC-P - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 2.0 - 10 ?g/mL.?For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration of 10 ?g/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
-
- Tokarew, J., et al. 2021. Acta Neuropathologica 2021. 141(5): 725-754. PubMed
- RRID
- AB_2820194 (BioLegend Cat. No. 870501) AB_2820195 (BioLegend Cat. No. 870502)
- Structure
- Human parkin is a 465 amino acid protein with a predicted molecular mass of ~52 kD.
- Distribution
-
Tissue distribution: Brain, heart, testis, and skeletal muscle
Cellular distribution: Cytosol, mitochondria, nucleus, and endoplasmic reticulum
- Function
- Parkin is involved in protein ubiquitination, protein degradation, mitochondria function, and neurodegeneration.
- Interaction
- Ubiquitin, PINK1
- Ligand/Receptor
- BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1
- Cell Type
- Neurons
- Biology Area
- Cell Biology, Mitochondrial Function, Neurodegeneration, Neuroinflammation, Neuroscience, Neuroscience Cell Markers, Protein Misfolding and Aggregation, Protein Trafficking and Clearance, Ubiquitin/Protein Degradation
- Molecular Family
- Ligases
- Antigen References
-
- Tay SP, et al. 2010. J Biol Chem. 285:29231-8.
- Pawlyk AC, et al. 2003. J Biol Chem. 278:48120-8
- Gene ID
- 5071 View all products for this Gene ID
- UniProt
- View information about Parkin on UniProt.org
