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Biotin anti-mouse CD16.2 (FcγRIV) Antibody
产品名称:
Biotin anti-mouse CD16.2 (FcγRIV) Antibody
产品类别:
抗体
产品编号:
149512
产品应用:
149512
[价格]
规格 价格 库存
100µg ¥ 3384 1

产品详情

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
FCγR4 —EC domain fusion with IgG1 Fc
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.125 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats of this clone) include: blocking of Fc?RIV function1 and inhibition of immune complex binding1,2. The LEAF? or Ultra-LEAF? purified antibody (Endotoxin < EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (contact our custom solutions team).

Application References

(PubMed link indicates BioLegend citation)
  1. Mancardi DA, et al. 2008. J. Clin. Invest 118:3738. (FC, Block)
  2. Nimmerjahn F, et al. 2005. Immunity 23:41.
RRID
AB_2632745 (BioLegend Cat. No. 149512)

Antigen Details

Structure
22.4 kD
Distribution

Expressed on peripheral blood leukocytes, spleen, colon, bone marrow, and the intestine

Function
Activating receptor for IgG2a and IgG2b via association with an ITAM bearing accessory.
Ligand/Receptor
IgG2a and IgG2b
Cell Type
B cells, Leukocytes
Biology Area
Immunology
Molecular Family
CD Molecules, Fc Receptors
Antigen References
  1. Mechetina LV, et al. 2002. Immunogenetics. 54:463-8.
  2. Nimmerjahn F, et al. 2005. Immunity. 23:41-51.
  3. Seeling M, et al. 2013. Proc. Natl. Acad. Sci. 110:10729-34.
Gene ID
246256 View all products for this Gene ID
UniProt
View information about CD16.2 on UniProt.org

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