PE/Cyanine7 anti-human CD326 (EpCAM) Antibody
- 产品名称：
- PE/Cyanine7 anti-human CD326 (EpCAM) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 324221
- 产品应用：
- 324221
[价格]
| 规格 |
价格 |
库存 |
| 25tests |
￥ 2112 |
1 |
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- DU.4475 breast carcinoma
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
Additional reported applications (for the revelant formats) include: immunofluorescence,?immunohistochemistry3, and spatial biology (IBEX)4,5.
- Additional Product Notes
- BioLegend is in the process of converting the name PE/Cy7 to PE/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our PE/Cyanine7 products. Please contact Technical Service if you have any questions.
- Application References
(PubMed link indicates BioLegend citation) -
- Lammers R, et al. 2002. Exp. Hematol. 30:537.
- Schultz LD, et al. 2010. P. Natl. Acad. Sci. USA 107:13022. PubMed
- Human Protein Atlas http://www.proteinatlas.org/ENSG00000119888/antibody (IHC)
- Radtke AJ,?et al. 2020.?Proc Natl Acad Sci USA. 117:33455-33465. (SB)?PubMed
- Radtke AJ,?et al. 2022.?Nat Protoc. 17:378-401. (SB)?PubMed
- Product Citations
-
- Penkava F, et al. 2020. Nat Commun. 3.76875. PubMed
- Zabala M, et al. 2020. Cell Stem Cell. 27(2):284-299.e8. PubMed
- Slamecka J, et al. 2017. Cell Cycle. 17:330. PubMed
- Xie T, et al. 2021. Sci Adv. 7: . PubMed
- Pham K, et al. 2016. Am J Pathol. 186: 1537-1546. PubMed
- Montoro DT, et al. 2018. Nature. 560:319. PubMed
- Wang D, et al. 2019. Cell Res. 29:832. PubMed
- Foster DS, et al. 2020. Nat Commun. 3.278472222. PubMed
- Bredenkamp N, et al. 2019. Stem Cell Reports. 1.29375. PubMed
- Marjanovic ND, et al. 2020. Cancer Cell. 38(2):229-246.e13. PubMed
- Tyagi N, et al. 2016. Cancer Lett. 370: 260-267. PubMed
- Nelson L, et al. 2020. Nat Commun. 1.029166667. PubMed
- Gao Y et al. 2018. Stem cell research. 28:161-164 . PubMed
- Dijkstra KK et al. 2018. Cell. 174(6):1586-1598 . PubMed
- Gradiz R, et al. 2016. Sci Rep. 6:21648. PubMed
- Lee HJ, et al. 2017. Oncotarget. 8:113345. PubMed
- Kure K, et al. 2020. Oncol Lett. 19:2286. PubMed
- Dangaj D, et al. 2019. Cancer Cell. 35:885. PubMed
- Howden S et al. 2019. Stem Cell Res. 1728:53:00 . PubMed
- Hosseini Far H et al. 2019. Stem Cell Res. 1727:49:00 . PubMed
- Cattaneo CM, et al. 2020. Nat Protoc. 15:15. PubMed
- Bharat A, et al. 2020. Science Translational Medicine. 12(574):. PubMed
- RRID
- AB_2561505 (BioLegend Cat. No. 324221) AB_2561506 (BioLegend Cat. No. 324222)
- Structure
- Type I transmembrane protein, contains six disulfide bridges, one THYRO domain, approximate molecular weight 40 kD.
- Distribution
-
Highly expressed in bone marrow, colon, lung, and most normal epithelial cells. Also highly expressed on carcinomas of gastrointestinal origin. Expressed during early erythrogenesis.
- Function
- Homotypic calcium-independent cell adhesion. CD326 is believed to be involved in carcinogenesis by its ability to induce genes involved in cellular metabolism and proliferation.
- Modification
- Glycosylated.
- Cell Type
- Embryonic Stem Cells, Epithelial cells
- Biology Area
- Cell Biology, Immunology, Stem Cells
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
-
1. Strnad J, et al. 1989. Cancer Res. 49:314.
2. Munz M, et al. 2004. Oncogene 23:5748.
3. Rao CG, et al. 2005. Int. J. Oncol. 27:49.
- Gene ID
- 4072 View all products for this Gene ID
- UniProt
- View information about CD326 on UniProt.org
