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首页 > 抗体蛋白 > 抗体
Purified anti-Bin1 Antibody
产品名称：
Purified anti-Bin1 Antibody
产品类别：
抗体
产品编号：
655602
产品应用：
655602
[价格]
规格 价格 库存
100µg ￥ 3180 1

产品详情

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Fragment of human Bin1
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

WB - Quality tested
IP, FC, ELISA - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 4.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Chapuis J, et al. 2013. Mol. Psychiatry doi: 10.1038/mp.2013.1.
RRID
AB_2562162 (BioLegend Cat. No. 655602)

Antigen Details

Structure
Ten isoforms, 409-593 amino acids, predicted molecular weight of 45-70 kD
Distribution

Isoforms 1-7 predominantly cytosolic, isoforms 8-10 found in both the nucleus and/or cytosol

Function
Plays important roles in membrane remodeling, cell polarity, programmed cell death, and stress signaling
Interaction
Heterodimer with AMPH; binds SH3GLB1, SYNJ1, DNM1, clathrin and AP2A2; interacts with MYC, BIN2 and HCV NS5A.
Ligand/Receptor
SH3GLB1
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Cell Cycle/DNA Replication, Cell Motility/Cytoskeleton/Structure, DNA Repair/Replication, Immunology, Signal Transduction, Transcription Factors
Antigen References

1. Kingwell K. 2013. Nature Reviews Neurology. 9:184.
2. Chapuis J, et al. 2013. Mol. Psychiatry doi: 10.1038/mp.2013.1.
3. Schellenberg GD and Montine TJ. 2012. Acta. Neuropathol. 124:305.
4. Ganesan S. 2011. Sci. Signal. 4:15.
5. Cowling BS, et al. 2012. PLoS. Genet. 8:e1002595.
6. Lambert JC and Amouyel P. 2011. Curr. Opin. Genet. Dev. 21:295.
7. Romero NB. 2010. Neuromuscul. Disord. 20:223.
8. Prendergast GC, et al. 2009. Biochim. Biophys. Acta. 1795:25.

Gene ID
274 View all products for this Gene ID
UniProt
View information about Bin1 on UniProt.org

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