APC anti-mouse CD317 (BST2, PDCA-1) Antibody
- 产品名称：
- APC anti-mouse CD317 (BST2, PDCA-1) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 127015
- 产品应用：
- 127015
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Mouse plasmacytoid dendritic cells (DCs)
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.06 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Red Laser (633 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: immunofluorescence microscopy, functional assay2, and depletion3,4. The Ultra-LEAF? purified antibody (Endotoxin <0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays.
- Application References
(PubMed link indicates BioLegend citation) -
- Blasius AL, et al. 2006. J. Immunol. 177:3260.
- Schliemann C, et al. 2010. Blood 115:736. (FA, IF)
- Rajagopal D, et al. 2010. Blood 115:1949. (Depletion)
- Moniz RJ, et al. 2010. FEMS Immunol. Med. Microbiol. 58:397. (Depletion)
- Chen YL, et al. 2013. J Exp Med. 210:2515. PubMed
- Product Citations
-
- Wagner C, et al. 2020. Cell Reports. 31(1):107479. PubMed
- Kitagawa S, et al. 2022. NPJ Vaccines. 7:115. PubMed
- R?dahl I, et al. 2021. STAR Protoc. 2:100842. PubMed
- Go DM, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:715. PubMed
- Findlay EG, et al. 2019. Oncoimmunology. 8:1608106. PubMed
- Han Y, et al. 2015. J Immunol. 195: 4126 - 4135. PubMed
- Billi AC, et al. 2019. JCI Insight. 4:8. PubMed
- Grzelak A, et al. 2018. Int J Mol Sci. 19:. PubMed
- Mulas F, et al. 2020. Cell Mol Immunol. . PubMed
- Sauma D, et al. 2017. Immunol Res. 10.1007/s12026-017-8936-9. PubMed
- Martínez‐López M et al. 2019. Immunity. 50(2):446-461 . PubMed
- Matsuda T, et al. 2022. iScience. 25:105324. PubMed
- Hirata SI, et al. 2020. Allergy. 75:1939. PubMed
- Yang P et al. 2019. Cell Syst. 8(5):427-445 . PubMed
- Bi E, et al. 2018. J Clin Invest. 128:4821. PubMed
- Walker MT, et al. 2021. Front. Allergy. 2:. PubMed
- Younes AI, et al. 2021. Transl Oncol. 14:100983. PubMed
- Chen R, et al. 2021. Front Oncol. 11:743050. PubMed
- Conrad C, et al. 2018. Nat Commun. 9:25. PubMed
- RRID
- AB_1967101 (BioLegend Cat. No. 127015) AB_1967127 (BioLegend Cat. No. 127016)
- Structure
- Type II transmembrane glycoprotein with a molecular mass of 29-33 kD.
- Distribution
-
Expressed on type I IFN-producing cells, plasmacytoid dendritic cells, and neoplastic B cells, such as multiple myeloma.
- Function
- Recently identified antiviral protein that blocks the release of nascent retrovirus or other particles from infected cells.
- Cell Type
- Dendritic cells
- Biology Area
- Costimulatory Molecules, Immunology, Innate Immunity
- Molecular Family
- CD Molecules
- Antigen References
-
1. Douglas JL. et al. 2009. J Virol. 83(16):7931
2. Cao W et al. 2009. J. Exp. Med. 206(7):1603
3. Neil SJ. et al. 2008. Nature 451:425
- Gene ID
- 69550 View all products for this Gene ID
- UniProt
- View information about CD317 on UniProt.org
