Purified anti-LRRK2 Antibody (Previously Covance c-上海雅吉生物科技有限公司

规格	价格	库存
25µL	￥ 1272	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Antibody is against amino acids 100 - 500 of human LRRK2.

Formulation

Phosphate-buffered solution.

Preparation

The antibody was purified by affinity chromatography.

Concentration

1 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.

Application

WB - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 2.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations

Wang X, et al. 2021. Sci Rep. 11:12900. PubMed

RRID

AB_2750047 (BioLegend Cat. No. 844402) AB_2565614 (BioLegend Cat. No. 844401)

Antigen Details

Structure

This gene is a member of the leucine-rich repeat kinase family and is encoded by the PARK8 gene. The protein is present mainly in the cytoplasm but can be associated with the mitochondrial outer membrane.
Expected MW: >200 kD

Distribution

Tissue distribution: Lung, Kidney, parathyroid gland, CNS
Cellular distribution: cytoplasm, mitochondrion, nucleus, endoplasmic reticulum, lysosome, Golgi apparatus, endosome

Function

LRRK2 interacts with the C-terminal R2 RING finger domain of parkin. LRRK2 positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. Mutations in this gene have been associated with Parkinson disease.

Biology Area

Cell Biology, Mitochondrial Function, Neuroinflammation, Neuroscience, Neuroscience Cell Markers

Molecular Family

Mitochondrial Markers

Antigen References