PE anti-mouse CD272 (BTLA) Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25µg	￥ 1608	1

Product Details

Verified Reactivity

Mouse

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

C57BL/6 BTLA Ig domain protein in CFA

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.

Concentration

0.2 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser

Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)

Application References (PubMed link indicates BioLegend citation)

Hurchla MA, et al. 2005. J. Immunol. 174:3377

Product Citations

Celis‐Gutierrez J et al. 2019. Cell Rep. 27(11):3315-3330 . PubMed
Stienne C, et al. 2022. Cell Rep. 38:110553. PubMed

RRID

AB_1731958 (BioLegend Cat. No. 134803) AB_1731884 (BioLegend Cat. No. 134804)

Antigen Details

Structure: An Ig superfamily coinhitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4.
Distribution: BTLA is expressed on a wide number of lymphocytes in mice. It is most highly expressed on B cells, followed by CD4+T cells, lower express on CD8⁺ T cells, macrophages, dendritic cells, NKT cells, and NK cells.
Function: BTLA functions as a negative regulator of T cell activation and proliferation. It attenuates B cell proliferation upon associating with its known ligand, Herpes Virus Entry Mediator (HVEM).
Ligand/Receptor: Herpes Virus Entry Mediator (HVEM)
Cell Type: Lymphocytes, B cells, T cells, Dendritic cells, NKT cells
Biology Area: Immunology, Inhibitory Molecules
Molecular Family: CD Molecules
Antigen References: 1. Liu X, et al. 2009. J. Immunol. 182:4516
2. Miller ML, et al. 2009. J. Immunol. 183:32
3. Sun Y, et al. 2009. J. Immunol. 183:1946
4. Vendel AC, et al. 2009. J. Immunol. 182:1509
5. Watanabe N, et al. 2003. Nat. Immunol. 4(7):670
6. Sedy JR, et al. 2005. Nat Immunol. 6(1):90
Gene ID: 208154 View all products for this Gene ID
UniProt: View information about CD272 on UniProt.org

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