Purified anti-human/mouse/rat MR1 Antibody
- 产品名称：
- Purified anti-human/mouse/rat MR1 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 396102
- 产品应用：
- 396102
- Verified Reactivity
- Human, Mouse, Rat
- Reported Reactivity
- Cow
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Chimeric mMR1/L molecule (mMR1 [alpha1-alpha2 domain]/Ld [alpha3 cytoplasmic tail]) soluble, recombinant protein secreted by insect cells was used to immunize MR1 KO mice
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This antibody is noted to cross-react to over-expressed mouse, rat, bovine (cow) and human MR11. This clone does not cross-block clone 26.5 based on in-house testing.
- Application References
(PubMed link indicates BioLegend citation) -
- Chua WJ, et al. 2011. J Immunol. 186:4744-50
- RRID
- AB_2810598 (BioLegend Cat. No. 396102)
- Structure
- Member of the MHC class I family, 1 Ig-like C1-type domain, forms heterodimer with B-2 Microglobulin.
- Distribution
-
MR1 transcripts are ubiquitously expressed, but its expression in the cell surface seems to be ligand-dependent.
- Function
- Antigen presentation, required for development and expansion of the mucosal-associated invariant T (MAIT) cells.
- Ligand/Receptor
- α-mannosyl ceramide derivatives, 6-formyl pterin, derivatives from bacterial riboflavin biosynthetic pathway).
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- MHC Antigens
- Antigen References
-
- Gold MC and Lewinsohn DM. 2013. Nat Rev Microbiol. 11:14.
- Young MH and Gapin L. 2013. Cell Res. 23:460.
- Gold MC, et al. 2013. Mucosal Immunol. 6:35.
- Meierovics A, et al. 2013. Proc Natl Acad Sci USA. 110:E3119.
- Gene ID
- 3140 View all products for this Gene ID 15064 View all products for this Gene ID 25119 View all products for this Gene ID
- UniProt
- View information about MR1 on UniProt.org
